Nanoparticles scaffolds

Hong R, Fischer NO, Verma A, Goodman CM, Emrick T, RoteUo VM. Control of protein structure and function through surface recognition by tailored nanoparticle scaffolds. J Am Chem Soc 2004 126 739-743. 

Drechsler U, Erdogan B, Rotello VM. Nanoparticles scaffolds for molecular recognition. Chem Eur J 2004 10 5570-5579. 

Shenhar R, Rotello VM. Nanoparticles scaffolds and building blocks. Acc Chem Res 2003 36 549-561. 

DrechslerU Erdogan B Rotello VM, Nanoparticles Scaffolds for molecular recognition, Chem.-Eur. J., 2004,10, 5570-5579. 

Boal AK, Rotello VM (2000) Fabrication and self-optimization of multivalent receptors on nanoparticle scaffolds. J Am Chem Soc 122 734—735... 

Rocha de Oliveira AA, de Carvalho SM, Leite MDF, Oreflce RL, Pereira MDM. Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications. J Biomed Mater Res Part B Appl Biomater July 2012 100B(5) 1387-96. 

Shenhar, R., Rotello, V. M. Nanoparticles Scaffolds and building blocks. Acc Chem... 

Nanosized objects perform various functions in the biomedical field. In the human body, nanosized particulate substances behave very differently from larger particles. In 1986, Maeda et al. found that the stained albumin, having a size of several nanometers, naturally accumulates in the region of cancerous tissues, which is now well known as the enhanced permeability and retention (EPR) effect. Many studies in the field of nanoparticles are based on this finding. Another application of nanoparticles is the delivery system using various polyplexes that are composed of carrier molecules and plasmid DNA or nucleic acid drugs such as antisenses and siRNA. In addition, nanofibers are mainly used for biodegradable scaffolds in tissue... 

In general, silver clusters in solution are prepared by reduction of silver ions. Proper scaffolds, e.g., DNA, proteins, dendrimers and polymers, are essential to prevent the aggregation of clusters to larger nanoparticles. Although it is clear that the emission originates from few-atom silver clusters, many aspects of this exciting class of nanoscopic metals are not yet fully understood. 

In this chapter, we discuss first how the silver clusters relate to silver atoms and silver nanoparticles. Then we overview the formation of fluorescent silver clusters in aqueous solution, using silver salts as precursors and various scaffolds as stabilizers. Finally we discuss applications of silver clusters in fluorescent labeling of biological tissues, and their use as fluorescent probes for sensing of molecules. 

The major issue is the formation of silver clusters in situ in the presence of the biomolecule to be labeled. On one hand, this problem is due to the fact that only a few scaffolds are suitable systems providing the proper environment for the formation of these very small species and preventing the formation of larger silver nanoparticles. On the other hand, the biomolecules might be harmfully... 

Zhang, N., et ah, Assembly of CdS nanoparticles on the two-dimensional graphene scaffold as visible-tight-driven photocatalyst for selective organic transformation under ambient conditions. The Journal of Physical Chemistry C, 2011.115(47) p. 23501-23511. 

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