Bioactive products, from marine

Kobayashi J, Tsuda M, Ishibashi M (1999) Bioactive Products from Marine Micro- and Macro-organisms. Pure Appl Chem 71 1123... 

Tan LT (2007) Bioactive natural products from marine cyanobacteria for drug discovery. Phytochem 68 954-979... 

Novel Bioactive Natural Products from Marine and Terrestrial Sources... 

The study of marine natural products has great possibilities for new products. Thus, Paul Scheuer from Hawaii studied bioactive compounds from mollusks and other marine sources. Luigi Minale, Raffaele Riccio and Maria lorizzi from Italy, conducted a comprehensive research on marine steroidal glycosides. Joel Kashman from Tel-Aviv University investigated on the biologically active natural products from marine organisms. 

Osterhages work has led to further analysis of bioactive products from the marine fungus A. salicorniae. In addition to the novel tetramic acid derivatives (38, 39), this fungus also produces two new epimeric lactones, the cycloethers ascolactone A (43) and B (44), similar to known cephalosporide compounds, and ascochitine (45), ascochital (46), and halopyrone (47), which were previously known.Compound 45 exhibited moderate inhibition of a tyrosine phosphatase B from Mycobacterium tuberculosis. 

Bioactive peptides as products of hydrolysis of diverse marine invertebrate (shellfish, crustacean, rotifer, etc.) proteins are the focus of current research. After much research on these muscles and byproducts, some biologically active peptides were identified and applied to useful compounds for human utilization. This chapter reviews bioactive peptides from marine invertebrates in regarding to their bioactivities. Additionally, specific characteristics of antihypertensive, anti-Alzheimer, antioxidant, antimicrobial peptide enzymatic production, methods to evaluate bioactivity capacity, bioavailability, and safety concerns of peptides are reviewed. 

This suggests that products with bioactive peptides derived from marine invertebrates can meet the needs of marine organism-derived products due to health and/or religious reasons. From such a viewpoint, hydrolysates or bioactive peptides from marine invertebrates can be interesting sources of bioactivity peptides in the treatment of chronic diseases. 

Owing to the immense diversity of animals and microbes in the marine environments, and their almost untouched capacity to produce natural products, the importance for marine pharmaceutical and nutra-ceutical industries was realized on a broad basis by the scientific communities recently. This has strengthened worldwide research activities on the exploration of bioactive compounds from marine organisms for pharmaceutical use, as well as the development of other valuable products, such as enzymes, nutraceuticals, and cosmeceuticals. 

Tan LT (2007) Bioactive Natural Products from Marine Cyanobacteria for Drug Discovery. Phytochemistry 68 954... 

Pomponi, S. A., Willoughby, R., Kaighn, M. E., and Wright, A. E., Development of techniques for in vitro production of bioactive natural products from marine sponges, in Invertebrate Cell Culture Novel Directions and Biotechnology Applications, Maramorosch, K. and Mitsuhashi, J., Eds., Academic Press, New York, 1997. 

The discovery that several major anticancer drugs, originally isolated from plants, are produced by associated endophytic fungi (Section III.B.3.) opens up further avenues for exploring the large-scale production of plant-derived pharmaceuticals. Likewise, the probable role of microbial symbionts in the production of bioactive agents from marine macroorganisms (Section III.B.4.) offers... 

The articles contained in this volume include the interaction of alkaloids with neuroreceptors and ion channels, anthracyclines suited for antibody-directed enzyme prodrug therapy and metabolites from soilborne fungi. Several articles are concerned with bioactive natural products from marine sources. The other areas covered include natural products with polyene amide structures, potential hypoglycemic agents, biological activity of essential oils, bioactive saponins and biologically active diterpenoids. 

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