Bioactive coatings

Other clinical studies have been focused on the artificial tympanic membrane application, ventilation mbes, an adhesion Barrier, elastic bioactive coatings on load-bearing dental and hip implants, and also for wound healing purposes. ... 

A. Ignatius, M. Peraus, S. Schorlemmer, P. Augat, W. Burger, S. Leyen, L. Claes, Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions. Biomaterials 26 (2005) 2325-2332. 

Thierry B, Winnik FM, Merhi Y et al, Bioactive coatings of endovascular stents based on polyelectrolyte multilayers. Biomacromolecules 2003 4 1564-1571. 

Jessel N, Atalar F, Lavalle P et al (2003) Bioactive coating based on a polyelectrolyte multilayer architecture functionalized by embedded proteins. Adv Mater 15 692-695... 

Glasses and ceramics can bond to living tissues if there is bioactive layer. The development of a bioactive hydroxyapatite layer in vivo at body temperature is therefore an important problem.89 Materials with the highest level of bioactivity develop a silica layer that enhances the formation of such a layer. Such sol-gel processes are used to produce bioactive coatings, powders and substrates which allow molecular control over the incorporation and behavior of proteins and cells with applications as sensors and implants. Sol-gel encapsulation of biomolecules within silica matrices has encompassed... 

Dunne, C.F., Twomey, B., O Neill, L., and Stanton, K.T. (2014) Co-blasting of titanium surfaces with an abrasive and hydroxyapatite to produced bioactive coatings substrate and coating characterisation. ). Biomater. Appl., 28 (5), 767-778. 

Guo, M.Q., Wang, H.F., Chen, W.Y., and Li, Y.B. (2014) Facile fabrication of gradient bioactive coating with hierarchically porous structure and superior cell response. Mater. Lett, doi 10.1016/j.matlet.2014.06.168... 

In the following paragraphs, the medical procedures utilised are described in much detail. There are many similar studies available in the literature that were designed to test and optimise in vivo the biomedical performance of bioactive coating systems. To avoid being overly repetitive, only a very few of these studies will be dealt with in this section. 

Bucher, R., and Britton, D.T. (2001) Defect structural characterization of plasma-sprayed bioactive coatings. Mater. Sci. Forum, 363/365, 502-504. 

Bumgardner JD et al (2003) Chitosan potential use as a bioactive coating for orthopaedic and craniofacial/dental implants. J Biomater Sci Polym Ed 14(5) 423 38... 

Jun S-H et al (2010) A bioactive coating of a silica xerogel/chitosan hybrid on titanium by a room temperature sol-gel process. Acta Biomater 6 302-307... 

Massey, S., E. Gallino, P. Cloutier et al. 2010. Low-energy electrons and x-ray irradiation effects on plasma-polymerized allylamine bioactive coatings for stents. Polym Degrad Stab 95 153-163. 

J. Lahann, H. Hocker, and R. Langer. Synthesis of amino[2.2]paracyclo-phanes - beneficial monomers for bioactive coating of medical implant materials. Angew. Chem. Int. Ed., 40 726-728, 2001. 

Precipitation techniqnes are suitable for preparing large areas of biocompatible or bioactive coatings at low temperatures (e.g., body temperature). The techniques usually include aqueous reactions of different reagents that form solid-state precipitates and in situ deposition of the precipitates onto a material. For example, hydroxyapatite nanocrystals can be prodnced by the coprecipitation of Ca(NOj)2 and (NH ) HPO mixtnre and fnrther deposited onto titanium implant surface to form an osteoconduc-tive nanocoating [48]. 

In the past few decades, plasma spray-coating techniques have been developed to cover orthopedic implants with protective and/or bioactive coatings. As introduced in Chapter 1, the plasma spray-coating method employs high temperature plasma jet to melt and spray a feedstock material onto a substrate to form a coating. The feedstock materials for plasma spray can be in the forms of solid, liquid or suspension [29,30]. For the fabrication of nanocoating on orthopedic implants, the commonly used solid... 

In vivo biosensors for glucose based on derivatized conducting polymers were also pursued. Yasuzawa et al. [64] synthesized pyrrole monomers that were derivatized with the phosphotidylcholine group to function as hemocompatible biosensors. This moiety is the principal component of the outer leaflet of red blood cell membranes. Subsequent electropolymerization of the pyrrole derivatives in the presence of glucose oxidase formed the outer bioactive coating of a glucose biosensor that also contained an inner membrane of Nafion. The combination of these membranes resulted in enhanced selectivity and retention of enzyme activity. 

Albumin, alkyl chains, fiuorocarbons, hydrogels, silica-free silicones, silicone oils Bioactive coatings... 

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