Bioactive bone cement

T. Yamamuro, T. Nakamura, H. lida, K. Kawanabe, Y. Matsuda, K. Ido, J. Tamura, Y. Seneba, Development of bioactive bone cement and its clinical applications. Biomaterials 19 (1998) 1479-1482. 

H. Fujita, T. Nakamura, J. Tamura, M. Kobayashi, Y. Katsura, T. Kokubo, T. Kikutani, Bioactive bone cement Effect of the amount of glass-ceramic pow/der on bonebonding strength, J. Biomed. Mater. Res. 40 (1998) 145-152. 

In a recent article [Shinzato, S., et al., A new bioactive bone cement Effect of glass bead filler content on mechanical and biological properties, J. Biomed. 

Figure 15.23 shows that an increased amount of glass filler increases the affinity index of bioactive bone cement. Because fillers are relatively inert they have the potential to improve biocompatibility of artificially produced materials. Figure... 

M. Saito, A. Maruoka, T. Mori, N. Sugano, K. Hino, Experimental studies on a new bioactive bone cement hydroxyapatite composite resin. Biomaterials 15 (1994) 156-160. 

Kokubo, T., and Yoshihara, S. (1991) Bioactive bone cement based on Ca0-Si02-P205 glass. Journal of the American Ceramic Society 74,1739-1741. 

Shinzato, S., Kobayashi. M., Mousa, W.F., Kamimura, M., Neo, M.. Choju, K., Kokubo, T., and Nakamura, T. (2000) Bioactive bone cement effect of surface curing properties on bone-bonding strength. J. Biomed. Mater. Res., 53 (1), 51-61. 

With low density, high tensile strength, compressive strength, and Ilexibihty, carbon fibers are potential candidates for bone reconstmction. To increase the mechanical strength of common implants, L. Syam Sundar et al. [63] dispersed a small fraction of carbon nanotubes into a PMMA/HA nanocomposite and showed that the concentration of 0.1% of MWCNTs performs the best reinforcement for the PMMA/HA nanocomposites. The hardness and elastic modulus of MWCNTs-reinforced PMMA/HA nanocomposites increase with the increasing concentration of nanotubes up to around 0.1% in weight. In vivo animal studies show that new bone (MWCNT/PMMA/HA nanocomposites) extended into the bioactive bone cement. 

Kawanabe K, Tamura J, Yamamuro T, Nakamura T, Kokubo T, Yoshihara S. New bioactive bone cement consisting of bis-GMA resin and bioactive glass powder. J Appl Biomater 1993 4 135 1. 

Mousa, W. E, M. Kobayashi, S. Shinzato et al. 2000. Biological and mechanical properties of PMMA-based bioactive bone cements. Biomaterials. 21 2137-46. 

Goto, K., J. Tamura, S. Shinzato, S. Fujibayashi, M. Hashimoto, M. Kawashita, T. Kokubo, and T. Nakamura. 2005. Bioactive bone cements containing nano-sized titania particles for use as bone substitutes. 

Deb, S., Aiyathurai, L., Roether, J.A., Luklinska, Z.B., 2005. Development of high-viscosity, two-paste bioactive bone cements. Biomaterials 26, 3713-3718. 

Bioactive PMMA bone cement prepared by modification with methacryloxypropyltrimethoxy silane and calcium chloride. Journal of Biomedical Materials Research, 67A, 1417-1423. 

Mori, A., Ohtsuki, C., Sugino, A., Kuramoto, K., Miyazaki, T., Tanihara, M. and Osaka, A. (2003)Bioactive PMMA-based bone cement modified with methacryloxypropyltrimethoxysilane and calcium salts — Effects of calcium salts on apatite-forming ability. Journal of the Ceramic Society of Japan, 111, 738-742. 

A. Sugino, C. Ohtsuki, T. Miyazaki, In vivo response of bioactive PMMA-based bone cement modified with alkoxysilane and calcium acetate, J. Biomater. Appl. 23 (3) (2008) 213-228. 

Bioceramic coatings are often used on metallic substrates in which the fracture toughness of the metal is combined with the ability of the coating to present a bioactive surface to the surrounding tissue. The use of a bioceramic coating on a metal implant can lead to earlier stabilization of the implant in the surrounding bone and extend the functional life of the prosthesis. Under the proper conditions a cementless prosthesis should remain functional longer than a cemented device in which stability is threatened by fracture of the bone cement. 

Bioactive composites Bioactive composite bone cement Ca3Si05 with /3Ca3(P04)2, Ca(H2P04)2 H20 Bone Huan and Chang (2009), Zhao eta/. (2005)... 

Huan, Z. Chang, J. (2009) Novel bioactive composite bone cements based on the beta-tricalcium phosphate-monocalcium phosphate monohydrate composite cement system. Acta Biomater, 5, 1253-64. 

The bioactivity of the PCL-Si02 hybrid system demonstrated by the formation of a layer of hydroxyapatite on the surface of samples soaked in a fluid simulating the composition of human blood plasma [358, 361]. Studies on the bioactivity of PMMA-Si02 nanohybrid materials has indicated that they are suitable materials for use as bioactive bone substitutes or as nanofillers for PMMA bone cement [362]. 

Furthermore, PMMA-Ca0-Si02 nanohybrid materials were shown to be suitable for bone cement and dental composite resin applications, due to their good bioactivity and improved mechanical properties [363]. PDMS-zirconia nanohybrids were proposed as suitable materials for tissue-implant integration purposes because they have beneficial effects on the proliferation and viability of human primary osteoblast and fibroblast cells and thus can be used as promising coatings for orthopedic trauma implants [364]. 

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