Bio informatics

Certainly biomolecular NMR is not the single method which is important for hit identification in pharmaceutical research. It is always a combination of techniques and a team effort that leads to a successful drug. This can involve biologists (basic understanding, assay development, bio-informatics), chemists (both bench chemists and modelers), screening specialists (HTS/natural products) and spectroscopists (X-ray, optical methods, surface plasmon resonance, NMR). 

Rodriguez, R., Chinea, G., Lopez, N., Pons, T., and Vriend, G. (1998) Homology modeling, model and software evaluation three related resources. Bio informatics 14, 523-528. 

Augen, J., 2005, Bio informatics in the post-genomic era Genome, transcriptome, proteome, and information-based medicine, Addison-Wesley. 

Ezekiel Adebiyi Bio-informatic Research Group, Department of Computer and Information Sciences, Covenant University, Ota, Nigeria Marion Adebiyi Bio-informatic Research Group, Department of Computer and Information Sciences, Covenant University, Ota, Nigeria Rommie E. Amaro Department of Chemistry and Biochemistry,... 

Collaborative Drug Discovery, Burlingame, CA, USA Segun Fatumo Bio-informatic Research Group, Department of Computer... 

I thank Jeremy Packer of the BioFocus Pic Bio informatics Group for casting a critical eye over the manuscript before it went for review and Sue Scott for her proofreading skills. 

Comparative QSAR at the interface between chemistry and biology (chem-bio-informatics) 02CRV783. 

With the advent of the human genome sequence a certain amount of hype has surrounded the field of bio informatics. The non-scientific media have... 

Mount, D. W. (2001) Bio informatics Sequence and Genome Analysis. Cold Spring Harbour Laboratory Press, Cold Spring Harbour, New York. 

The domain services layer provides life-sciences-specific services, such as bio-informatics and cheminformatics applications and data, and tools that can be utilized to build and maintain the life sciences data and analytical models. There are a number of notable projects that can be utilized to provide components to build out an... 

Pedretti, A.L., Villa, G., and Vistoli, G. 2004. VEGA—An open platform to develop chemo-bio-informatics applications, using plug-in architecture and script programming. J. Comput. Aided Mol. Des. 18 167-173. 

The sensitive requirements for exposure assessment have been met by the recent development of mass spectrometry (MS) techniques for the characterisation of proteins expressed by a genome, tissue or cell. Of particular interest is the matrix-assisted laser-desorption/ionisation (MALDI), which makes it possible to obtain protein mass fingerprinting for a wide range of proteins by MS. This method involves selectively cutting proteins by enzymatic actions, and comparing the fragment masses with theoretical peptides available in bio-informatic databases. 

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