Beta2-microglobulin

Jones, E. M., and Surewicz, W. K. (2005). Fibril conformation as the basis of species- and strain-dependent seeding specificity of mammalian prion amyloids. Cell 121, 63-72. Kad, N. M., Myers, S. L., Smith, D. P., Smith, D. A., Radford, S. E., and Thomson, N. H. (2003). Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy./. Mol. Biol. 330, 785-797. 

Ivanova, M. I., Gingery, M., Whitson, L. J., and Eisenberg, D. (2003). Role of the C-terminal 28 residues of beta2-microglobulin in amyloid fibril formation. Biochemistry 42, 13536-13540. 

Jones, S., Manning, J., Kad, N. M., and Radford, S. E. (2003). Amyloid-forming peptides from beta2-microglobulin-Insights into the mechanism of fibril formation in vitro. J. Mol. Biol. 325, 249-257. 

Monti, M., Principe, S., Giorgetti, S., Mangione, P., Merlini, G., Clark, A., Bellotti, V., Amoresano, A., and Pucci, P. (2002). Topological investigation of amyloid fibrils obtained from beta2-microglobulin. Protein Sci. 11, 2362-2369. 

Glimm H, Eisterer W, Lee K, et al. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SClD-beta2 microglobulin-null mice. J Clin Invest. 2001 107 199-206. 

Chaussidon M, Netter P, Kessler M, et al. 1993. Dialysis-associated arthropathy Secondary ion mass spectrometry evidence of aluminum silicate in beta2-microglobulin amyloid synovial tissue and articular cartilage. Nephron 65 559-563. 

Junghans RP, Anderson CL. The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor. Proc Natl Acad Sci USA 1996 93(ll) 5512-6. 

Zhu X, Peng J, Raychowdhury R, Nakajima A, Lencer WI, Blumberg RS. The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association. Biochem J 2002 367(Pt 3) 703-14. 

The pathogenesis of methotrexate-induced nephrotoxicity is not understood, but it is thought to result from crystallization of methotrexate in the renal tubules. Adequate hydration and urinary alkalinization are necessary to minimize this effect (61). Urinary beta2 microglobulin may be a useful marker of methotrexate nephrotoxicity (62). 

Transient renal tubular dysfunction has been reported in a patient with asthma requiring mechanical ventilation who received sevoflurane for 9 days (36). Soda hme was not used, and the cumulative dose was 298 MAC-hours. Serum and urinary inorganic fluoride concentrations reached maximum concentrations of 71 and 2047 pmoPl respectively. Markers of renal tubular injury were also greatly raised (urinary A-acetyl-beta-o-glucosaminidase and beta2-microglobulin). However, urine volume, creatinine clearance, and serum creatinine and urea concentrations were unaffected. 

Nomura T, Huang WC, Seo S, Zhau HE, Mimata H, Chung LW. Targeting beta2-microglobulin mediated signaling as a novel therapeutic approach for human renal cell carcinoma. J Ureol 2007 178 292-300. 

Hall PW, Vasiljevic M. Beta2-microglobulin excretion as an index of renal tubular disorders with special reference to endemic Balkan nephropathy. J Lab Clin Med 1973 81 897-904. 

Gussow, D Rein, R., Ginjaar, I., Hochstenbach, F Seeman, G., Kottman, A., and Ploegh, H. L. (1987) The human beta2-microglobulin gene. Primary structure and definition of the transcriptional unit. J. Immunol. 139, 3132-3138. 

Beta2-microglobulin (BMG) is a low molecular weight (11,8 kDa) protein found on tire cell surfaces of all nucleated cells and shed into the blood, particularly by B lymphocytes and some tumor cells. 

Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G (2010) Urinary clusterin, cys-tatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol 28(5) 463-469. doi 10.1038/nbt. 1622... 

Stopeck AT, Jones A, Hersh EM, Thompson JA, Einucane DM, GutheH JC, Gonzalez R. Phase II study of direct intralesional gene transfer of aUovectin-7, an HLA-B7/beta2-microglobulin DNA-Uposome complex, in patients with metastatic melanoma. Clin Cancer Res. 2001 7(8) 2285-91. 

Cheung AK, Agodoa LY, Daugirdas JT, et al. Effects of hemodialyzer reuse on clearances of urea and beta2-microglobulin. The Hemodialysis (HEMO) Study Group. J Am Soc Nephrol 1999 10 117-127. 

Borysik, A.J. Read, R Little, D.R. Bateman, R.H. Radford, S.E. Ashcroft, A.E. Separation of beta2-microglobulin conformers by high-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to electrospray ionization mass spectrometry. Rapid Commun. Mass Spectmm. 2004,18, 2229-2234. 

Gatanaga H, Tachikawa N, Kikuchi Y, Teruya K, Genka I, Honda M, Tanuma J, Yazaki H, Ueda A, Kimura S, Oka S (2006) Urinary beta2-microglobulin as a possible sensitive marker for renal injury caused by tenofovir disoproxil fumarate. AIDS Res Hum Retrovimses... 

Wendler, T., Duhr, C., and Bosch, T. (2003). Ex vivo biocompatibility of a new beta2-microglobulin hemoperfusion polymer. Int. J. Artif. Organs 26, 467. 

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