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Urinary Clusterin

In the kidney, clusterin is a component of immune deposits and its expression is increased after ischemia or obstruction. In gentamicin-treated rats, an increase in urinary clusterin protein may provide an early sign of nephrotoxicity [336]. In rats with unilatertral ureteral obstruction, clusterin mRNA and clusterin-beta have been detected in the kidney along with clusterin-alpha in the urine [337]. A central role for glomerular clusterin as a modulator of inflammation that potentially influences the chnical outcome in human membranous glomerulonephritis has been described [338]. [Pg.116]

Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G (2010) Urinary clusterin, cys-tatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol 28(5) 463-469. doi 10.1038/nbt. 1622... [Pg.473]

Hidaka S, Kranzlin B, Gietz N, Witzgall R (2002) Urinary clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries. Cell Tissue Res 310 289-296... [Pg.349]

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Clusterin

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