Benzyl-L-glutamate

Synthesis. Using hexamethyl amine as initiator, we have copolymerized, in DNF solution, the N-carboxy-anhydride [NCA] of benzyl -L-glutamate with the NCAs of the following amino acids cinnamyl-L-glutamate, carbobenzoxy-L-lysine, L-leucine, dL-phenyl alanin, L-phenyl alanin. [Pg.169]

To obtain block copolymers, we copolymerize successively the NCAs of the two a amino acids. At the end of the polymerization of the first block we protect the NHp terminus by an D-nitrophenyl-sulphenyl group to allow its fractionation and its characterization. After elimination of the protecting group we polymerize the NCA of the second amino acid. [Pg.169]

To obtain random copolymers, we polymerize simultaneously the NCAs of the two amino acids and we follow the copolymer composition during polymerization to be sure that it remains nearly constant and that there is no formation of blocks. [Pg.169]

Structure. All the random and block copolymers we have synthesized exhibit liquid crystalline structures in dioxane. [Pg.169]

We have not studied the cholesteric phases found between about 50 % and 80 % of solvent for some copolymers, because X-Ray diffraction patterns of this phase are very poor [one observes only a band at low angles) and do not allow a detailed analysis of the cholesteric structure. [Pg.169]

The intrinsic viscosity of poly(7-benzyl-L-glutamate) (Mq = 219) shows such a strong molecular weight dependence in dimethyl formamide that the polymer was suspected to exist as a helix which approximates a prolate ellipsoid of revolution in its hydrodynamic behaviorf ... [Pg.652]

Poly(7-benzyl-L-glutamate) is known to possess a helical structure in certain solvents. As part of an investigationf of this molecule, a fractionated sample was examined in chloroform (CHCI3) and chloroform saturated ( 0.5%) with dimethyl formamide (DMF). The following results were obtained ... [Pg.708]

Polymer Solutions. Perhaps the most extensively studied macromolecular Hquid crystals are the synthetic polypeptides, such as poly( y-benzyl L-glutamate) [25513-40-0] (PBLG). PBLG is a homopolymer of the L-enantiomorph of a single amino acid with the foUowiag repeat unit. [Pg.201]

PVL Pivalolactone, Bz-L-G-NCA 7-benzyl-L-glutamate NCA. GAS Glycolic acid anhydrosulfite. [Pg.4]

Recently, Gallot et al. succeeded in preparing well characterized block copolymers by polymerization of 7-benzyl-L-glutamate NCA and e-carbobenzoxyl-L-lysine NCA with a primary amine ended polystyrene or polybutadiene in dioxane or ben-... [Pg.32]

Certain polymers will exhibit liquid crystal behaviour in solution. This phenomenon was first noted for natural polypeptides, but was found to be obtainable in synthetic systems initially for poly(7-benzyl L-glutamate)... [Pg.157]

C34H4(,N207 82637-57-8) see Moexipril y-benzyl L-glutamate (C12H15NO4 1676-73-9) see Cilazapril benzylhydrazine... [Pg.2305]

Papadopoulos, P. etal. Nanodomain-induced chain folding poly(gamma-benzyl-L-glutamate)-b-polyglycine diblock copolymers. Biomacromolecules, 6, 2352, 2005. [Pg.215]

Block, H., Poly(Y-benzyl-L-glutamate) and Other Glutamic Acid Containing Polymers. Gordon and Breach, New York, 1983,... [Pg.226]

Kros A, Jesse W, Metselaar GA, Comelissen JJLM (2005) Synthesis and self-assembly of rod-rod hybrid poly(gamma-benzyl L-glutamate)-block-polyisocyanide copolymers. Angew Chem hit Ed 44 4349 352... [Pg.25]

Kim KT, Vandermeulen GWM, Winnik MA, Manners I (2005) Organometallic-polypeptide block copolymers synthesis and properties of poly(ferrocenyldimethylsilane)-b-poly (gamma-benzyl-L-glutamate). Macromolecules 38 4958 961... [Pg.25]

Mori H, Iwata M, Ito S, Endo T (2007) Ring-opening polymerization of gamma-benzyl-L-glutamate-N-carboxyanhydride in ionic liquids. Polymer 48 5867-5877... [Pg.26]

Upadhyay KK, Bhatt AN, Mishra AK, Dwarakanath BS, Jain S, Schatz C, Le Meins JE, Earooque A, Chandraiah G, Jain AK, Misra A, Lecommandoux S (2010) The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(y-benzyl L-glutamate)-b-hyaluronan polymersomes. Biomaterials 31(10) 2882... [Pg.134]

For aprotic polar organic solvents only few widely applicable alignment media are known. The lyotropic mesophase of poly(y-benzyl-L-glutamate) (PBLG) with DMF [37] has the disadvantage of a relatively strong minimum alignment. Bicellar... [Pg.220]

Panar, M., Phillips, W. D. Magnetic ordering of poly-y-benzyl-L-glutamate solutions. /. Am. Chem. Soc. 1968, 90, 3880-3882. [Pg.248]

PolyCy-benzyl L-glutamate) (PBLG), 15 109 Poly(y-ketosulfide)s, optically active, 23 711 Poly(P-alanine), 1 292 Poly-P-hydroxybutyrate (PHB), 12 482 Polybetaines, 20 479-482 applications of, 20 482 preparation of, 20 480-481 solution properties of, 20 481-482 synthesis of, 20 479-481 Polyborates, 4 256-258 Polyborosiloxanes, in silicon carbide manufacture and processing, 22 533 Polybrominated diphenyl ethers (PBDEs), 13 142-143 20 56... [Pg.725]

Local Dynamics in Polypeptides Studied by Solid State 2H NMR Side Chain Dynamics of Poly(Y-benzyl L-glutamate) and Racemic Poly(Y-benzyl glutamate)... [Pg.297]

R Ledger, FHC Stewart. The preparation of substituted y-benzyl L-glutamates and 13-benzyl L-aspartates. (copper(II)) Aust J Chem 18, 1477, 1965. [Pg.196]

Fig. 33. Zimm plot128) for a sample of poly-7-benzyl-L-glutamate in dimethyl formamide at 25 °C...

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