3- Benzoyl propionic acid

An interesting consideration relating to the influence of acidity in the reaction medium is derived from the comparison between the conditions adopted for the synthesis of the P-aminoketoncs 44 and 45, and tho.se required for the analogous derivatives that lack the carboxy group. Whereas the latter compounds are prepared under the. severe conditions of type A (Table 6), both the syntheses of 44, employing glyoxal as aldehyde reagent,and that of 45, which is prepared from 3-benzoyl propionic acid, take place readily under mild conditions (type B or C). 

C10H10N2 2-methyl-7-quinolinamine 64334-96-9 46 67 1.1606 2 19185 C10H10O3 3-benzoyl propionic acid 2051-95-8 44.33 1.1531 2... 

C10H10O trans-4-phenyl-3-buten-2-one 1896-62-4 53415 47.175 1,2 19185 Cl OH1003 3-benzoyl propionic acid 2051-95-8 498.78 43.766 2... 

The ethyl 7-veratrylbutyrate, b.p. 203-207°/20 mm., is obtained in 80% yield by esterification of 7-veratrylbutyric acid by the Fischer-Speier method. The 7-veratrylbutyric acid is prepared by the method of E. L. Martin from /3-(3,4-dimethoxy-benzoyl)-propionic acid. 

Almost simultaneously, workers at Geigy A.-G.38 and Oeberli and Houlihan3 and Houlihan40-42 reported the condensation of y-benzoyl-propionic acids (74) with 1,3-diaminopropane (71) to give substituted 8a-phenyl- l,2,3,4,6,7,8a-octahydropyrrolo[l,2-a]pyrimidin-6-one (75) [Eq. (21). ... 

Feitbufen >-Oxo-fI i biphenyl) 4 butanoic acid 3-(4-biphenyly)carbony])prOpionic acid /9-p-phenyl-benzoyl propionic acid diphenyl-4- -oxo-7-butyric acid 4-(4-biphenylyl) 4-oxobutyrfc acid CL 82204 Bufemid Cinopal Cinopol Lederfen. mol wt 254.29. C... 

A mixture of 36.5 g methyl (S)-3-[4-(l-methylpropyl)benzoyl]propionate (0.147 mol) dissolved in 600 mL glacial acetic acid and 725 mL 36% HCl was heated at 70°C for 8 h. After the mixture was cooled, 10 L of water was added the organic product was extracted with ether, washed by water and dried evaporation gave 33.6 g (S)-3-[4-(l-methylpropyl)benzoyl]propionic acid, in a yield of 97%, m.p. 94-95°C. 

Benzoyl-2,3-dihydro-lH-pyrrolizine-l-cai boxylic acid (ketorolac, L ) and 2-(3-benzoyl-phenyl)propionic acid (ketoprofen, L ) ai e biologically activ ligands used in medicine as non-steroidal anti-inflammatory dmgs. 

Methyloxindole has been prepared by the reduction of a-(2-nitro-phenyl)propionic acid,2 by heating j8-propionylphenylhydrazine with lime3 or with sodium alkoxides,4 and by reduction of the benzoyl derivative of oxindole-3-aldehyde.6... 

A wide variety of monomers, such as (3,5-dibromophenyl)boronic acid, 3,5-bis(trimethylsiloxy)benzoyl chloride, 3,5-diacetoxybenzoic acid, and 2,2-dimethylol propionic acid have been used for the synthesis of hyperbranched polymers. A selection of these polymers are described in Sect. 3. The majority of the polymers are synthesized via step-wise polymerizations where A B monomers are bulk-polymerized in the presence of a suitable catalyst, typically an acid or a transesterification reagent. To accomphsh a satisfactory conversion, the low molecular weight condensation product formed during the reaction has to be removed. This is most often achieved by a flow of argon or by reducing the pressure in the reaction flask. The resulting polymer is usually used without any purification or, in some cases, after precipitation of the dissolved reaction mixture into a non-solvent. 

The main group of methods for the preparation of a 1,2,4-oxadiazole ring is based on cyclization of amidoxime derivatives in the presence of acylating agents °. A surprisingly easy cyclization of O-benzoyl-/ -piperidinopropioamidoxime 247 to oxadiazole 248 in DMSO at room temperature was described (equation 107) . 3-(3-Aryl-1,2,4-oxadiazol-5-yl)propionic acids 250 were obtained by the reaction of amidoximes 249 with succinic anhydride under microwave irradiation or conventional heating (equation 108) °°. 

F.) for agitated propionic acid (0.5M), l-benzoyl-2-ethylaziridine (0.5M) in toluene with 18.5 wt. % ammonium perchlorate... 

Benzoyl-phenyl)-propionic acid, 3-benzoyl-a-methylbenzene-acetic acid, C16H14O3, Mr 254.28, mp 94 °C lysine salt (1 1) [57469-78-0], C16H14O3. C6H14N2O2, Mr 400.47 sodium salt [57495-14-4], C16Hi3Na03, Mr 276.27... 

In addition to aryl carboxylic acids, including profens (2-aryl propionic acid NS AIDs) (see Fig. 9.36) [393,398], the terguride-based CSP has shown the potential to re.solve the enantiomers of 2-aryloxypropionic acids [394] and of A-dansyl, A-3,5-dinitrobenzoyl, A-benzoyl, A-P-naphthoyl amino acid derivatives [395]. 

Ethylsiliconic acid or Silico-propionic acid is obtained from ethyl triethoxy silicon using benzoyl chloride at 300 C. ... 

In an earlier study of the effects of imipenem in the rabbit kidney it was shown that imipenem caused a significant decrease of mitochondrial respiration, deplehon of reduced glutathione, increased production of oxidized glutathione and lipid peroxidation [56]. However, these effects were less than those produced by a comparable nephrotoxic dose of cephaloridine [56]. Panipenem induced nephrotoxicity at a dose of 200 mg/kg, i.v., but this was less severe than that caused by a single dose of imipenem [57]. Simultaneous adminis-trahon of p-mipron (N-benzoyl-3-propionic acid) with imipenem and panipenem reduced the nephrotoxicity of these carbapenems by inhibiting the active transport of carbapenems in the renal cortex [57]. 

Approximately 3 g of benzoyl peroxide are added to 20 kg of wheat flour. This is then easily decomposed to benzoic acid and other substances such as biphenyl and phenylbenzoate (Be-Onishi et al., 2004). Aqueous solutions of 2.5% of the sodium salts of organic acids are adequate to maintain the chemical quality and extend the shelf life of fresh salmon with only minor sensory changes during refrigerated storage (Sallam, 2007b). In carcass surface applications 2% lactic, 1.5% acetic plus 1.5% propionic acids are usually applied (Dubai et al., 2004). 

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