Belladonna extract

Bellacane Elixir—atropine, scopolamine HBr, hyoseyamine HBr or sulfate, phenobarbital, alcohol, tartrazine Bellacane SR Tablets—1-alkaloids of belladonna, phenobarbital, ergotamine tartrate Bellergal-S Tablets—1-alkaloids of belladonna, phenobarbital, ergotamine tartrate Butibel Elixir—belladonna extract, butabarbital sodium, alcohol, sucrose, saccharin Butibel Tablets—belladonna extract, butabarbitol Chardonna-2 Tablets—belladonna extract, phenobarbital Donnatal Elixir—atropine, scopolamine HBr, hyoseyamine HBr or sulfate, phenobarbital, alcohol, sucrose, saccharin... 

Fig. 1 Reflectance scan of a chromatogram track of an Atmpa belladonna extract (A) and of a reference track (B) with 200 ng of both atropine (1) and scopolamine (2).

What would be the displacement value of belladonna extract if it is known that six suppositories containing 60 mg each of the drug weigh... 

Dosing substances to the eye is a technique performed since the start of civilization. First eye cosmetics have been described around 1550 bc by the ancient Egyptians. Later, eye preparations for women (e.g., containing belladonna extracts) have been described during the Baroque period of Europe. Major importance for eye medications was gained through the discovery of alkaloids in the nineteenth century. Since then, eye medications always played a major role in therapeutics. 

In contrast to muscarine, atropine blocks these actions of acetylcholine and muscarine. Atropine is, therefore, an acetylcholine antagonist. It binds where acetylcholine binds and therefore prevents the binding of the latter but does not activate it. Two molecules cannot occupy the same binding site at the same time. Atropine is isolated from the plant Atropa belladonna. Extracts of this plant have been used for millennia for a variety of purposes. Although large doses are poisonous (Atropos is the name of the Fate who cuts the thread of life), small doses causes dilation of the pupils, a consequence of its action as an acetylcholine antagonist, and has been used for cosmetic purposes by women, hi Itahan, belladonna means beautiful woman. 

Belladonna extract Bulk and tablets GC buffer pH 2.0 (3 2) Dissolve in acid USP-G3... 

Ext. Belladonna (extract of belladonna) The active agent Is atropine. In neuralgia. It was preferred over opium. Used In cases of whooping cough, scarlet fever, spasmodic asthma, and other Instances calling for an antlspasmodic. 

She had also started to take a combined formulation containing ergotamine (0.6 mg/day), phenobarbital (40 mg/day), and belladonna extract (0.4 mg/day). Four days later she noted pain in both legs and all her extremities were cold, pale, and pulseless. She had diffuse arterial spasm in the aorta and all four limbs. Despite intensive vasodilator therapy, she developed bilateral gangrene of the toes, requiring transmetatarsal amputations. 

Wyatt et al. worked out a GLC assay for atropine and scopolamine in belladonna extract. The extract was solved in 0.1 N sulphuric acid, homatropine hydrobromide was added to this solution as an internal standard, and interfering materials were extracted from the acidified solution with chloroform - and finally a mixture of chloroform and 2-propanol (10 3) if there is an emulsion problem. The alkaloids were subsequently extracted into chloroform (or chloroform-2-propanol) from the basified aqueous layer (pH 9.5 phosphate buffer was used instead of mineral alkali to minimize ester cleavage) and the chloroform extracts were filtered through anhydrous sodium sulphate (previously washed with chloroform). 87 % of the alkaloids were recovered in the first extract, so that two additional extractions gave suffi-... 

CONTENT OF ATROPINE, SCOPOLAMINE AND TOTAL ALKALOIDS IN BELLADONNA EXTRACTS DETERMINED BY... 

Lotion of Belladonna. Extract of deadly night-shade, 1 drachm diluted solution of diacotatc of lead, 1 pint dissolve. Applied to tumors and glandular enlargements. 

During a celebrated 1893 murder trial, prosecutors conducted an experiment before the jury. They administered a lethal dose of morphine to a cat, and, as its life ebbed away, they applied a few drops of belladonna extract to its eyes. Why ... 

Aloe and aloin are extensively used as active ingredients in laxative preparations, often with other cathartics such as buckthorn, cascara, and senna belladonna extracts are often included to lessen griping. Aloin is also used in antiobesity preparations. 

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