Baicalein, effect

Flavonoid baicalein, which is believed to be one of the most important components of Japanese Kampo (traditional herbal) medicine, was found to be an effective scavenger of superoxide and hydroxyl radicals and the inhibitor of iron-induced in vivo lipid peroxidation in gerbils [122],... 

Anti-hepatitis B virus activity in vitro and in vivo was also found in wogonin and baicalein (Fig. 4), the major active constituents of the traditional Chinese medicine Scutellaria radix.More recently, Blach-Olszewska et al investigated the effect of baicalein and wogonin on two important mechanisms of innate immunity The secretion of cytokines, and the natural resistance of human leukocytes to viral infection. The results obtained indicate that these fiavonoids modulate cytokine production, that is they inhibit interferons-a and -y, and stimulate tumor necrosis factor-a and interleukin production. They also augment the resistance of peripheral blood leukocytes to the vesicular stomatitis virus. 

Shinichi, I., S. Kaxunobu, Y. Naomasa, Y. Ryouji, W. Seiji, Y. Keisuke, and K. Taketoshi. 2000. Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology 55 951-955. 

Some flavonoids (baicalein, myricetin, quercetagenin and scutellarein) under certain conditions may exert vasoconstrictor rather than vasodilator effects [122]. As described above, myricetin has been shown to exhibit a biphasic response in pre-contracted rat thoracic aorta. At low... 

Studies have shown that quercetin, kaempferol, and fisetin inhibited transcription with RNA polymerase II in permeabilized normal human fibroblasts (WI-38 cells) flavone and chrysin exhibited weak activity. Addition of quercetin to an ongoing transcription reaction arrested it promptly, suggesting that quercetin was inhibiting the elongation step. The effects of several flavonoids (quercetin, quercetagetin, myricetin, and baicalein) exhibited complex interactions with DNA and RNA polymerases, depending on the particular flavonoid and the enzyme species. 

To clarify the inhibitory effects of these flavonoids from Scutellariae radix on adjuvant-induced arthritis, we further examined the effects of these flavonoids on leukotriene synthesis and adhesion molecular expression in neutrophils and vein endothelial cells. Baicalein inhibited the biosynthesis of LTs B4 and C4 in human leukocytes most strongly... 

Fig. (48). Effects of baicalein and baicalin isolated from the roots of Scutellaria baicalensis on adjuvant-induced arthritis in rats.

Fig. (50). Effects of baicalein on tumor necrosis factor- (X and intereukin 1 /3 -induced...

Table 16. Effects of baicalein and baicalin on the endotoxin-induced disseminated intravascular coagulation (DIG) in rats...

Table 14. Effects of PKC inhibitor H7 and baicalein on ELAM-1 and ICAM-1 expression induced by PMA, thrombin and TRAP in cultured HUVECs1...

Fig. ( 2). Effects of baicalein on thrombin-induced ELAM-1 and ICAM-1 expression in cultured HUVECs.

These findings suggest that the inhibitory effects of baicalein on thrombin-induced ELAM-1 and ICAM-1 expression, or TRAP-induced ELAM-1 expression, may be due to the inhibition of PKC activation. I previously reported that baicalein had potent anti-allergic and... 

S. baicalensis has yielded wogonin (53), baicalein (55) and baicalin (56). These flavonoids have both antiinflammatory effect and cause cellular activation, enhanced the synthesis of both collagen and total protein [26]. 

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