Baicalein

Flavonoid baicalein, which is believed to be one of the most important components of Japanese Kampo (traditional herbal) medicine, was found to be an effective scavenger of superoxide and hydroxyl radicals and the inhibitor of iron-induced in vivo lipid peroxidation in gerbils [122],... 

The retention behaviour of flavonoids has also been extensively studied on silica stationary phases using heptane, benzene or dichloromethane as weaker components of the binary mobile phase and ethyl acetate and methyl ethyl ketone as modifier. Flavones (3-hydroxy, 5-hydroxy and 7-hydroxyflavone, tectochrysin, chrysin, apigenin, genkwanin, baicalein), flavonols (galangin, pilloin, kaempferol, rhamnetin, quercetin, robinetin,... 

Anti-hepatitis B virus activity in vitro and in vivo was also found in wogonin and baicalein (Fig. 4), the major active constituents of the traditional Chinese medicine Scutellaria radix.More recently, Blach-Olszewska et al investigated the effect of baicalein and wogonin on two important mechanisms of innate immunity The secretion of cytokines, and the natural resistance of human leukocytes to viral infection. The results obtained indicate that these fiavonoids modulate cytokine production, that is they inhibit interferons-a and -y, and stimulate tumor necrosis factor-a and interleukin production. They also augment the resistance of peripheral blood leukocytes to the vesicular stomatitis virus. 

Nishioka T, Kawabata J, Aoyama Y. (1998) Baicalein, an a-glucosidase inhibitor from Scutellaria baicalensis. J Nat Prod 61 1413-1415. 

Baicahn and baicalein in rat plasma honokiol and magnolol in branches and leaves of Magnolia obovata quercetin in human plasma ... 

Kotani, A., Kojima, S., Hakamata, H., and Kusu, R, HPLC with electrochemical detection to examine the pharmacokinetics of baicalin and baicalein in rat plasma after oral administration of a Kampo medicine. Analytical Biochemistry 350(1), 99-104, 2006. 

Aoyama. Baicalein, an alpha-glucosi-dase inhibitor from Scutelaria baical-ensis. J Nat Prod 1998 61(11) 1413-1415. 

Glucosyl(l 3)rhamnoside Baicalein 7-methyl ether (negletein)... 

Scutellaria baicalensis Georgi S. macrantha Fisch. China Baicalein, baicalin, wogonin, beta-sitosterol, wognoside, 7-methoxy-baicalein, 7-methoxynorwogonin, skullcap flavones.33 Antibacterial, antiviral, antipyretic, antiinflammatory, antitumor. 

N.A. Scutellarin, baicalin, baicalein, wogonin, benzoic acid, catapol, tannins, beta-sitosterol, camphesterol, stigmas terol.99-102 163 Sedative and antispasmodic, prevent epileptic seizures, antiallergic. 

Shinichi, I., S. Kaxunobu, Y. Naomasa, Y. Ryouji, W. Seiji, Y. Keisuke, and K. Taketoshi. 2000. Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology 55 951-955. 

Eupatin (69, R = H) and Eupatoretin (69, R = CH3), which are isolated from thistle perennials, show moderate cytotoxicity against human carcinoma of the nasopharynx (236). Baicalein (70) salts exhibit antialleigic and antiinflammatory activity. 3,4,5-Trimethoxyphenoxyacetamides are hypotensives and diuretics and are useful for controlling arrhythmia during anesthesia (237). 

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