Baicalein from Scutellariae radix

To clarify the inhibitory effects of these flavonoids from Scutellariae radix on adjuvant-induced arthritis, we further examined the effects of these flavonoids on leukotriene synthesis and adhesion molecular expression in neutrophils and vein endothelial cells. Baicalein inhibited the biosynthesis of LTs B4 and C4 in human leukocytes most strongly... 

Flavonoids are major components of Scutellaria radix, and about 40 kinds of flavonoids have been identified in it so far [5]. These flavonoids are known to have a broad range of physiological activities. The activities of baicalin, which is the main component, baicalein, and wogonin, in particular, have been investigated. From the results, it has been concluded that the most potent antiallergic material is baicalein, and the other flavonoids have low activities. Therefore, the quantitative analysis of individual flavonoids is important for evaluating the quality of Scutellaria radix. Figures 1 and 2 show the HPLC... 

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