Baicalein 5,6,7-trihydroxyflavone

Baicalein (= 5,6,7-Trihydroxyflavone) (flavone) Scutellaria spp. (Lamiaceae), Oroxylum indicum (Bignoniaceae) Aminopeptidase N (57% inhibition at 300 pM) [63]... 

MSA is derivatized with a diazonium salt to produce a diazosulfone, which is quantified by HPLC [157]. The flavonoids catechin, epicatechin, 7,8-dihydroxyflavone, and rutin showed a OH scavenging activity 100 to 300 times higher than mannitol, whereas baicalein (5,6,7-trihydroxyflavone), quercetin, myricetin, and morin enhanced the OH production [16]. The pro-oxidant activity of morin increased with an increasing concentration of morin, whereas an increasing concentration of the other three flavonoids did not enhance their pro-oxidant activity. Hanasaki et al. suggested that these pro-oxidant flavonoids produce H2O2 during their auto-oxidation, which then stimulates the Fenton reaction [16]. 

Some bioactive flavones include aldose reductase inhibitors (apigenin 4 -methyl ether (acacetin), apigenin 7-0-apioside (apiin), 5,7-dihydroxyflavone (chrysin) and luteolin) antiinflammatory 5-LOX inhibitors (5,6,7-trihydroxyflavone (baicalein), 5,6,3, 4 -tetrahydroxy 7-methoxyflavone (pedalitin), 5,3, 4 -trihydroxy 6,7-dimethoxyflavone (cirsiliol, 6-0-methylpedalitin) and flavone) a COX inhibitor (flavone) iodothyronine deiodinase inhibitors (acacetin, chrysin and luteolin) a NADH and succinate dehydrogenase inhibitor (luteolin) millet-derived, goitrogenic inhibitors of thyroid peroxidase (flavone C-glycosides orientin and vitexin) and protein kinase inhibitors (acacetin, apigenin, baicalein, flavone, luteolin, 5,7,3, 4, 5 -pentahydroxyflavone (tricetin) and tricetin 3, 4, 5 -trimethyl ether). 

Flavones are an important class of flavonoids, having the basic structure of 2-phenylchromen-4-one (2-phenyl-l-benzopyran-4-one). Naturally occurring flavones include apigenin (4, 5,7-trihydroxyflavone), luteolin (3, 4, 5,7-tetrahydroxyflavone), tangeritin (4, 5,6,7,8-penta-methoxyflavone), 6-hydroxyflavone, baicalein (5,6,7-trihydroxyfla-vone), chrysin (5,7-OH), wogonin (5,7-OH, 8-OCH3), and scutellarein (5,6,7,4 -tetrahydroxyflavone). Flavoxate and diosmin are synthetic flavones that are yellow in color. 

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