Bacterial protein histidine kinase

Trew SJ, Wrigley SK, Pairet L, Sohal J, Shanu-Wilson P, Hayes MA, Martin SM, Manohar RN, Chicarelli-Robinson MI, Kau DA, Byrne CV, Wellington EMH, Moloney JM, Howard J, Hupe D, Olson ER (2000) Novel Streptopyrroles from Streptomyces rimosus with Bacterial Protein Histidine Kinase Inhibitory and Antimicrobial Activities. J Antibiot 53 1... 

The natural product discovery experiences described here confirm that microorganisms continue to represent an abundant source of interesting signal transduction inhibitors. A variety of high-throughput screening approaches for the discovery of such compounds were used with varying results. The bacterial protein histidine kinase assay resulted in the... 

Siuette MG, Levit M, Liu Y, Lukat G, Ninfa EG, Ninla A, Stock JB. Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis. J Biol Qiem 1996 271 939-945. 

Phytochrome is found not only in higher plants but also in algae, where it controls the movement of chloroplasts,611 and also in cyanobacteria.623 54 Cyano-bacterial phytochromes contain histidine kinase domains, which may function in a two-component system with a response regulator similar to protein CheY of the chemotaxis system in E. coli (Fig. 19-5).624/625 Some nonphotosynthetic bacteria also use bacteriophytochromes for light sensing. In some cases biliverdin (Fig. 24-24) is the chromophore.6253... 

The sensor protein is NtrB (NRn), which is an auto-phosphorylating histidine kinase similar to the CheY protein of bacterial chemotaxis (Fig. 19-5). 

The bacterial chemoreceptor (Figs. 11-8 and 19-5) has a very small ligand-binding domain and a larger internal domain that activates a histidine kinase. Many growth-factor receptors, including the insulin receptor (Figs. 11-11,11-12), have internal domains with protein tyrosine kinase activity. 

In its active form CheA undergoes autophosphorylation, that is, the phosphorylation of a histidine imidazole group in one of its subunits by the protein kinase active site of an adjacent subunit. The phospho group is then transferred from phospho-CheA to another protein, CheY. Phospho-CheY interacts with the flagellar motor proteins (Chapter 19) periodically causing a reversal of direction of the bacterial flagella. As a result the bacteria tumble and then usually move... 

JJ Hillard, RM Goldschmidt, L Licata, EZ Baum, K Bush. Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems. Antimicrob Agents Chemother 43 1693-1699, 1999. 

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