Bacterial chemoreceptor

Figure 10.1. The membrane topology proposed for D. vulgaris Hildenborough DcrH based on hydrophathy analysis and sequence homologies to other bacterial chemoreceptors (Deckers and Voordouw 1996). Shaded boxes, putative membrane-spanning (residues 9-30 and 422 31), excitation (residues 653-692), and methylation (residues 757-764) regions. The C-terminal box (residues 824-959) indicates the Hr-like region. Reprinted with permission from Xiong et al. (2000), copyright 2000 American Chemical Society.

Chemoheterotrophic bacteria 8 Chemolithotrophic bacteria 7 Chemoprevention 575 Chemoreceptors 562s bacterial 561—563 Chemostat 470 Chemotaxis... 

The bacterial chemoreceptor (Figs. 11-8 and 19-5) has a very small ligand-binding domain and a larger internal domain that activates a histidine kinase. Many growth-factor receptors, including the insulin receptor (Figs. 11-11,11-12), have internal domains with protein tyrosine kinase activity. 

Ames, P. and Parkinson, J.S. (1988). Transmembrane signaling by bacterial chemoreceptors E. coli transducers with locked signal output. Cell 55, 817-826. Ames, P. and Parkinson, J.S. (1994). Constitutively signaling fragments of Tsr, the Escherichia coli serine chemoreceptor./. Bacteriol. 176, 6340—6348. 

Gestwicki, J.E. and Kiessling, L.L. (2002). Inter-receptor communication through arrays of bacterial chemoreceptors. Nature 415, 81-84. 

Hughson, A.G. and Hazelbauer, G.L. (1996). Detecting the conformational change of transmembrane signaling in a bacterial chemoreceptor by measuring effects on disulfide cross-linking in vivo. Proc. Natl. Acad. Sci. 17. S. A 93, 11546-11551. 

Kossmann, M., Wolff, C. and Manson, M.D. (1988). Maltose chemoreceptor of Escherichia coli Interaction of maltose-binding protein and the Tar signal transducer./. Bacterial. 170,4516-4521. 

Murphy, O.J., Kovacs, F.A., Sicard, E.L. and Thompson, L.K. (2001). Site-directed solid-state NMR measurement of a ligand-induced conformational change in the serine bacterial chemoreceptor. Biochemistry 40, 1358-1366. 

Kiessling and coworkers exploited the use of multivalent carbohydrates in studying the mechanism of signal transduction in bacterial chemotaxis. In bacterial chemotaxis, the high-abundance chemoreceptor Tsr mediates responses to the chemoattractant serine, while the low-abundance... 

The mechanistic basis of this remarkable sensitivity has remained puzzhng. It was proposed to be rooted in the lateral assemblies of bacterial chemoreceptors and signaling components within the plasma membrane [204]. To test this hypothesis, Kiessling and coworkers generated polymeric attractants to probe the consequences of perturbing chemoreceptor clustering. 

Seven transmembrane helices (7-TM) are a stmctural motif common to a large family of photo- and chemoreceptor proteins. Most prominent examples of 7-TM proteins include (bacterial) rhodopsins and G protein-coupled receptors (GPCRs). 

---