Axid - Nizatidine

Nizatidine. Nizatidine, or Axid [76963 1-2] (3), is an off-white to buff crystalline solid. It is soluble in water and its method of synthesis is available (4). 

These drug inhibit die action of histamine at histamine H2 receptor cells of die stomach, which then reduces die secretion of gastric acid and reduces total pepsin output. The decrease in acid allows the ulcerated areas to heal. Examples of histamine H2 antagonists include cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid Pulvules), ranitidine (Zantac). 

Like other drugs described above, nizatidine is used for treating stomach and duodenum ulcers and other conditions accompanied by elevated acidity of the gastrointestinal tract. Synonyms of this drug are axid and pulvules. 

Lansoprazole (Prevacid, Prevacid IV) Nizatidine (Axid, AxidAR)... 

Nizatidine (Axid/ Axid AR [OTC]) [Gastric Antisecretory/ H2 Receptor Antagonist] Uses Duodenal ulcCTs, GERD, heartburn Action H2-Receptor antagonist D< Adults. Active ulcer 150 mg PO bid or 300 mg PO hs maint 150 mg PO hs GERD 150 mg PO bid Heartburn 75 mg PO bid... 

Oral 10 mg tablets, gelcaps powder to reconstitute for 40 mg/5 mL suspension Parenteral 10 mg/mL for injection Nizatidine (generic, Axid, Axid AR )... 

There are two types of histamine receptors HI receptors, which are blocked by agents such as diphenhydramine and other antiallergic compounds, and H2 receptors, which are blocked by cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid), and nizatidine (Axid). Cimetidine has no effect on most 11, receptor-mediated effects, such as bronchoconstriction. 

The metabolism of lorazepam (e.g., Ativan), oxazepam (e.g., Serax), and temazepam (e.g., Restoril) are not likely to be affected, and one of these agents may be preferred when a benzodiazepine is indicated in a patient being treated with cimetidine. The experience with ranitidine (e.g., Zantac), famotidine (Pepcid), and nizatidine (Axid) suggests that these agents are not likely to inhibit hepatic enzyme systems, and these other histamine H2-receptor antagonists are less likely than cimetidine to interact with other drugs that are metabolized via these pathways. 

Axid AR (nizatidine) Whitehall-Robins Healthcare Stomach acid reducer... 

Nizatidine. Ni/atidine. (V- 2- 2-((dimethylantino) methyl l-4-thiazolyl Intethyllthio )ethyl -/ -ntcthyl-2-nitro-l.l-cthenediamine (Axid). is an off-white to buff crystalline solid that is. soluble in water, alcohol, and chloroform. The pK s of the drug in water are 2.1 (side chain) and 6.8 (di-methylamino). 

Trade names Apo-Nizatidine Axid (Reliant) Calmaxid Gastrax Nizax Nizaxid Panaxid Tazac Zanizal Indications Duodenal ulcer, Gastroesophageal Reflux Disease (GERD)... 

Nicotinex niacin nizatidine Apo-Nizatidine, Axid, Calmaxid, Gastrax, Nizax,... 

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