Nizatidine

Nizatidine. Nizatidine, or Axid [76963 1-2] (3), is an off-white to buff crystalline solid. It is soluble in water and its method of synthesis is available (4). 

These drug inhibit die action of histamine at histamine H2 receptor cells of die stomach, which then reduces die secretion of gastric acid and reduces total pepsin output. The decrease in acid allows the ulcerated areas to heal. Examples of histamine H2 antagonists include cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid Pulvules), ranitidine (Zantac). 

HISTAMINE H2 ANTAGONISTS. The nurse administers ranitidine and oral cimetidine before or with meals and at bedtime Nizatidine and famotidine are given at bedtime or, if twice-a-day dosing is prescribed, in the morning and at bedtime. These drugp are usually given concurrently with an antacid to relieve the pain. In certain situations or disorders, cimetidine and ranitidine may also be given by intermittent IV infusion or direct IV injection. 

A nurse is to administer nizatidine once daily. When would the nurse most correctly administer the once-daily dose of nizatidine ... 

CjiHisNO So 3285-33-4) see Tiotixene dimethy laminothioacetamide (C4Hh)N2S 27507-2S-4) see Nizatidine 4>dimethylamino-l-trimethylsUyl-l-butanone (CyH2tNOSi) see Rizatriptan benzoate (3p,17p)-7,17-dimethylandrast-5-enc-3,7,17-triol (C21H34O4 96613-61-5) see Calusterone dimethylaniline... 

Isolation cimetidine, famotidine, nizatidine, and ranitidine hydrochlorides... 

H2 receptor antagonists (Cimetidine, famotidine, nizatidine, ranitidine) Proton pump inhibitors Lansoprazole Omeprazole Pantoprazole Rabeprazole... 

Antacid/alginic acid (Gaviscon) 2 tablets or 1 5 mL after meals and at bedtime AND/OR C. Patient-directed therapy Over-the-counter H2RAs (each taken up to twice daily) - Cimetidine 200 mg - Lamotidine 1 0 mg - Nizatidine 75 mg - Ranitidine 75 mg OR Over-the-counter PPI (taken once daily) - Omeprazole 20 mg agent. 

The histamine2-receptor antagonists or H2RAs (cimetidine, famotidine, nizatidine, and ranitidine) and proton pump inhibitors (omeprazole, esomeprazole, lansoprazole, pantopra-zole, and rabeprazole) reduce the amount of acid secreted into the stomach by gastric parietal cells. These agents are also helpful for nausea and vomiting related to gastric acid secretion. 

Nakamura, H., Sano, H., Yamazaki, M., Sugiyama Y., Carrier-mediated active transport of histamine H2 receptor antagonists, cimetidine and nizatidine, into isolated rat hepato-cytes contribution of type I system,... 

Brummer RJ, Stockbruegger RW Effect of nizatidine 300 mg at night and omeprazole 20 mg in the morning on 24-hour intragastric pH and bacterial overgrowth in patients with acute duodenal ulcer. Dig Dis Sci 1996 41 2048-2054. 

Nwokolo CU, Smith JT, Gavey C, Sawyerr A, Pounder RE Tolerance during 29 days of conventional dosing with cimetidine, nizatidine, famotidine or ranitidine. Aliment Pharmacol Ther 1990 4(suppl 1) 29—45. 

Intermittent, mild heartburn Lifestyle modifications plus patient-directed therapy Antacids Maalox or Mylanta 30 mL as needed or after meals and at bedtime Gaviscon 2 tabs after meals and at bedtime Calcium carbonate 500 mg, 2-4 tablets as needed and/or Nonprescription 11 receptor antagonists (taken up to twice daily) Cimetidine 200 mg Famotidine 10 mg Nizatidine 75 mg Ranitidine 75 mg or... 

Symptomatic relief of GERD Nonprescription proton pump inhibitor (taken once daily) Omeprazole 20 mg Lifestyle modifications plus prescription-strength add suppression therapy H2-receptor antagonists (for 6-12 weeks) Cimetidine 400 mg twice daily Famotidine 20 mg twice daily Nizatidine 150 mg twice daily Ranitidine 150 mg twice daily... 

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