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Avian sarcoma virus

Adenovirus transcription factor (ATF) is a protein activated by the adenovirus protein E2a and has turned out to be CREB (cAMP-responsive, element-binding protein) Jun is named for avian sarcoma virus 17 (I am told that junana is 17 in Japanese). [Pg.252]

Erikson, R.L., Colett, M.S., Erikson, E. and Purchio, A.F. Evidence that the avian sarcoma virus transforming gene product is a cyclic AMP-independent protein kinase (1979) Proc. Natl.Acad.Sci. U.S.A. 76, 6260-6264... [Pg.283]

Many proteins and glycoproteins are first synthesized in the form of a protein that is larger than the final product. Here, the primary translation-product is subject to one or more steps of controlled proteolysis.430 Good model-systems for study of the conversion of a precursor protein into the final product are cells infected with enveloped viruses,229,431-435 such as influenza, Semliki Forest, Sindbis, and avian sarcoma viruses (and others). Some of these viruses stop synthesis of... [Pg.356]

Retroviruses have featured prominently in recent advances in the molecular understanding of cancer. Most retroviruses do not kill their host cells but remain integrated in the cellular DNA, replicating when the cell divides. Some retroviruses, classified as RNA tumor viruses, contain an oncogene that can cause the cell to grow abnormally (see Fig. 12-47). The first retrovirus of this type to be studied was the Rous sarcoma virus (also called avian sarcoma virus Fig. 26-31), named for F. Peyton Rous, who studied chicken tumors now known to be caused by this virus. Since the initial discovery of oncogenes by Flarold Varmus and Michael Bishop, many dozens of such genes have been found in retroviruses. [Pg.1023]

Ishimoto, N., Temin, H.M., and Strominger, J.L., Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts, J. Biol. Chem., 241, 2052, 1966. [Pg.276]

Crk is a protooncogene, related to v-crk, the oncogene of the avian sarcoma virus CTIO. Crk is the abbreviation of T regulator of ase. Although, Crk induces tyrosine phosphorylation, it is not a tyrosine kinase. It is actually a linker, containing SH2 and SH3 domains which links up with tyrosine kinases. [Pg.308]

Crystal structure of avian sarcoma virus integrase with bound essential eations... [Pg.417]

Bujacz, G., Jaskolski, M., Alexandratos, J., Wlodawer, A., Merkel, G., Katz, R. A., and Skalka, A. M. (1996). The catalytic domain of avian sarcoma virus integrase conformation of the active-site residues in the presence of divalent cations. Structure 4, 89-96. Kulkosky, J., Katz, R. A., Merkel, G., and Skalka, A. M. (1995). Activities and substrate specificity of the evolutionarily conserved central domain of retroviral integrase. Virology 206, 448-456,... [Pg.424]

Azaguanine-resistant avian sarcoma virus-infected cells were less tu-morigenic than nonresistant cells in hamsters. Incubation of cells (infected with adenoviruses in tissue culture) with 8-azaguanine (10 M) inhibited reproduction of the virus. At this concentration, the drug was not toxic for healthy mammalian cells. ... [Pg.178]

Figure 14. Mode of action of avian sarcoma virus integrase (courtesy R.A. Katz). The viral strands are drawn with thin lines, the host DNA is drawn with heavy lines. This diagram is highly simplified in that there is another insertion site on the other strand 6 base pairs away. The resultant nucleic acid is repaired after the action of integrase. Figure 14. Mode of action of avian sarcoma virus integrase (courtesy R.A. Katz). The viral strands are drawn with thin lines, the host DNA is drawn with heavy lines. This diagram is highly simplified in that there is another insertion site on the other strand 6 base pairs away. The resultant nucleic acid is repaired after the action of integrase.
Figure 15. Avian sarcoma virus (ASV) integrase. (a) Manganese ions in the active site of ASV integrase. Note that there are two examples of the metal ion-water-carboxylate motif in the coordination octahedron, (b) Zinc ions in the active site of ASV integrase. The two zinc ions are separated by water and the carboxylate group of Asp64. Figure 15. Avian sarcoma virus (ASV) integrase. (a) Manganese ions in the active site of ASV integrase. Note that there are two examples of the metal ion-water-carboxylate motif in the coordination octahedron, (b) Zinc ions in the active site of ASV integrase. The two zinc ions are separated by water and the carboxylate group of Asp64.
Avian erythroblastosis virus (strain ES4 [57,58]) [57, 58] <24> Avian sarcoma virus (strain PRCII [59]) [59]... [Pg.525]

Neil, J.C. Ghysdael, J. Vogt, P.K. Smart, J.E. Homologous tyrosine phosphorylation sites in transformation-specific gene products of distinct avian sarcoma viruses. Nature, 291, 675-677 (1981)... [Pg.576]

Takeya, T. Feldman, R.A. Hanafusa, H. DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an FcoRl fragment of recovered avian sarcoma virus which codes for gp37 and pp60src. J. Virol., 44, 1-11 (1982)... [Pg.576]

Kitamura, N. Kitamura, A. Toyoshima, K. Hirayama, Y. Yoshida, M. Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus. Nature, 297, 205-208 (1982)... [Pg.577]

Neckameyer, W.S. Wang, L.H. Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family. J. Virol., 53, 879-884 (1985)... [Pg.577]

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Avian sarcoma virus (ASV

Integrase avian sarcoma virus

Sarcoma virus

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