Hyaluronic acid synthetase

Tomida, M., Koyama, H., and Ono, T., Hyaluronate acid synthetase in cultured mammalian cells producing hyaluronic acid oscillatory change during the growth phase and suppression by 5-bromodeoxyuridine, Biochim. Biophys. Acta, 338, 352, 1974. 

Ishimoto, N., Temin, H.M., and Strominger, J.L., Studies of carcinogenesis by avian sarcoma viruses. II. Virus-induced increase in hyaluronic acid synthetase in chicken fibroblasts, J. Biol. Chem., 241, 2052, 1966. 

Prehm (1983a) also explored the release of hyaluronate from the membranes and showed the phosphate esters prevented shedding of hyaluronate chains during active synthesis, but not under conditions where synthesis could not proceed. Oligosaccharides from hyaluronic acid would not displace it from membrane-bound synthetase, but it was released by trypsin or detergents. Hyaluronate chains appeared to be released randomly during synthesis and there was a continuous initiation of new chains even after two hours of incubation of membranes. 

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