Autoantibody Epitopes

Lambert-Eaton syndrome is an antibody-mediated neuromuscular junction disorder. This disorder, which is most frequently encountered in patients with small-cell lung carcinoma, is characterized clinically by weakness and hyporeflexia. The impaired release of acetylcholine vesicles from presynaptic terminals at neuromuscular junctions that causes the weakness is a consequence of autoantibodies against small cell carcinoma epitopes that cross-react with and downregulate the expression of motor nerve terminal Ca2+ channels [39]. (See in Ch. 43.)... 

Lecoeur, S., Andre, C., and Beaune, P.H., Tienilic acid-induced autoimmune hepatitis Antiliver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9, Mol. Pharmacol., 50,326, 1996. 

The synovial arrays were incubated with the sera from patients with early and severe RA as well as healthy patients. Hierarchical clustering analysis revealed that autoreactive B-cell responses for citrullinated epitopes were present in a subset of patients with early RA, features which are predictive of the development of severe RA. In contrast, autoantibodies directed against native epitopes including several human cartilage gp39 peptides and type II collagen, were associated with features predictive of less severe RA. 

Fitchen, J., Beachy, R.N., and Hein, M.B. (1995). Plant vims expressing hybrid coat protein with added murine epitope elicits autoantibody response. Vaccine, 13 1051-7. 

Hoet, R.M.A., Raats, J.M.H., de Wildt, R., et al. (1998). Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the UlsnRNP associated U1C protein) epitope mapping, immunolocalization and V-gene usage. Mol. Immunol., 35, 1045-1055. 

Hoet, R.M., Pieffers, M., Stassen, M.H., et al. (1999). The importance of the light chain for the epitope specificity of human anti-Ul small nuclear RNA autoantibodies present in systemic lupus erythematosus patients. J. Immunol., 163, 3304—3312. 

Daw, K., Ujihara, N., Atkinson, M.A. and Powers, A.C. (1996) Glutamic acid decarboxylase autoantibodies in stiff man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition. J. Immunol., 156, 818-825. 

D14. Dorner, T., Feist, E., Wagenmann, A., Kato, T., Yamamoto, K., etal., Anti-52 kDa Ro(SSA) autoantibodies in different autoimmune diseases preferentially recognize epitopes on the central region of the antigen. J. Rheum. 23, 462-468 (1996). 

Welschof, M., Reineke, U., Kleist, C., et al. (1999) The antigen binding domain of non-idiotypic human anti-F(ab )2 autoantibodies Study of their interaction with IgG hinge region epitopes. Human Immunol. 60, 282-290. 

The analysis of the epitope repertoire of antibodies against tTG in CD patients was not, however, conclusive enough to allow the construction of peptide-based tests for estimation of autoantibodies [165 168],... 

Autoantibody responses against conformational epitopes of MOG have the power to destroy myelin, as demonstrated in the marmoset model of human MS... 

Szostecki, C., Will, H., Netter, H.J., Gnidner, H.H. Autoantibodies to the nuclear Sp 100 protein in primary biUary cirrhosis and associated disease epitope specificity and immunoglobulin class distribution. Scand. J. Immunol. 1992 36 555-564... 

M. Seccia, E. Albano, E. Maggi and G. Bellomo, Circulating Autoantibodies Recognizing Peroxidase-Oxidized Low Density Lipoprotein Evidence for New Antigenic Epitopes Formed in Vivo Independently From Lipid Peroxidation, Arteriosclerosis. Thrombosis, and Vascular Biolog 17(1997)134-140. 

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