Immunoglobulin classes

H, Devey ME Immunoglobulin class and subclass distribution of dextran-reactive antibodies in human reactors and non-reactors to clinical dex-tran. Allergy 1982 37 481-489. 

The Five Types of Heavy Chain Determine Immunoglobulin Class... 

Five classes of H chain have been found in humans (Table 50-7), distinguished by differences in their Cjl regions. They are designated y, a, i 5, and e. The i and e chains each have four domains rather than the usual three. The type of H chain determines the class of immunoglobulin and thus its effector function. There are thus five immunoglobulin classes IgG, IgA, IgM, IgD, and IgE. The biologic functions of these five classes are summarized in Table 50-8. 

Antibody classes In mammals, there are five classes of antibodies (also known as immunoglobulins IgG, IgA, IgM, IgE and IgD). Each immunoglobulin class differs in their heavy chain constant domains (see Fig. 1.2) and consequently in its biological properties. For immunoassays, two immuno-glubulin classes are of importance - IgG and IgM. 

FUNCTION MEDIATES B-CELL PROLIFERATION IN THE ABSENCE OF COSTIMULUS AS WELL AS IGE PRODUCTION IN THE PRESENCE OF IL-4. INVOLVED IN IMMUNOGLOBULIN CLASS SWITCHING. 

Control slides of known reactivity should be run with each set of slides immunostained. Appropriate controls should include an irrelevant antibody of the same immunoglobulin class at an equivalent concentration. 

Beh, K. J. 1973. Distribution of brucella antibody among immunoglobulin classes and a low molecular weight antibody fraction in serum and whey of cattle. Res. Vet. Sci. 14, 381-384. 

Hammer, D. K., Kickhoefen, B. and Schmid, T. 1971. Detection of homocytotropic antibody associated with a unique immunoglobulin class in the bovine species. Eur. J. Immunol. 1, 249-257. 

The principle of the screening test implies that the antimouse immunoglobulin solid phase has the capacity to recognize all mouse immunoglobulin classes and subclasses (see Note 4). 

Johansson SGO. 1967. Raised levels of a new immunoglobulin class (IgND) in asthma. Lancet. 2 951-953. 

Leid, R.W. and Williams, J.F. (1 974) The immunological response of the rat to infection with Taenia taeniae-formis. I. Immunoglobulin classes involved in passive transfer of resistance. Immunology 27, 195-208. 

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