ATSDR

Toxicological Profle forMercuy, ATSDR/TP-89/16, Agency for Toxic Substances and Disease Registry, U.S. PubHc Health Service, Adanta, Ga., 1989. 

Make sure to pay a visit to the Agency for Toxic Substances and Disease Registry (ATSDR). You can perform quick searches by clicking onto the first letter of a chemical listed. The web-site address is the following http //atsdr 1.atsdr.cdc.gov 8080/toxfaq.html. This site also provides some links to other sites with chemical specific information and health risk data. 

ATSDR Case Studies in Environmental Medicine, Lum, M, Ortyl D, Project Officers, published by the Agency for Toxic Substances and Disease Registry. 

ATSDR s Toxicological Profiles on compact disc. (Lewis Publishers, 1997 CRC Press, Inc.). 

Agency for Toxic Substances and Disease Registry (ATSDR)... 

Hotline +1 404 639 6360, 24-hour emergency number. E-mail atsdric cdc.gov Web site www.atsdr.cdc.gov... 

A more thorough review of analytical methods can be found in ATSDR (2003). Sample detection limits for biological material are typically in the range of 1-5... 

Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at ... 

The toxicological profiles are developed in response to the Superfund Amendments and Reauthorization Act (SARA) of 1986 (Public law 99-499) which amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund). This public law directed ATSDR to prepared toxicological profiles for hazardous substances most commonly found at facilities on the CERCLA National Priorities List and that pose the most significant potential threat to human health, as determined by ATSDR and the EPA. The availability of the revised priority list of 275 hazardous substances was announced in the Federal Register on November 17, 1997 (62 FR 61332). For prior versions of the list of substances, see Federal RegisternoiiCQS dated April 29, 1996 (61 FR 18744) April 17, 1987 (52 FR 12866) October 20, 1988 (53 FR 41280) October 26, 1989 (54 FR 43619) October 17, 1990 (55 FR 42067) October 17, 1991 (56 FR 52166) October 28, 1992 (57 FR 48801) and February 28, 1994 (59 FR 9486). Section 104(i)(3) of CERCLA, as amended, directs the Administrator of ATSDR to prepare a toxicological profile for each substance on the list. 

The following additional material can be ordered through the ATSDR Information Center ... 

THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS ... 

Scientists from the Agency for Toxic Substances and Disease Registry (ATSDR) have reviewed the peer reviewers comments and determined which comments will be included in the profile. A listing of the peer reviewers comments not incorporated in the profile, with a brief explanation of the rationale for their exclusion, exists as part of the administrative record for this compound. A list of databases reviewed and a list of unpublished documents cited are also included in the administrative record. 

The citation of the peer review panel should not be understood to imply its approval of the profile s final content. The responsibility for the content of this profile lies with the ATSDR. 

ATSDR can also tell you the location of occupational and environmental health clinics. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. 

Although methods have been established to derive these levels (Barnes and Dourson 1988 EPA 1990c), uncertainties are associated with these techniques. Furthermore, ATSDR acknowledges additional uncertainties inherent in the application of the procedures to derive less than lifetime MRLs. As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as h q)ersensitivity reactions, asthma, or chronic bronchitis. As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. 

Section 104(i)(5) of CERCLA, as amended, directs the Administrator of ATSDR (in consultation with the Administrator of EPA and agencies and programs of the Public Health Service) to assess whether adequate information on the health effects of methyl parathion is available. Where adequate information is not available, ATSDR, in conjunction with the National Toxicology Program (NTP), is required to assure the initiation of a program of research designed to determine the health effects (and techniques for developing methods to determine such health effects) of methyl parathion. 

The following categories of possible data needs have been identified by a joint team of scientists from ATSDR, NTP, and EPA. They are defined as substance-specific informational needs that if met would reduce the uncertainties of human health assessment. This definition should not be interpreted to mean that all data needs discussed in this section must be filled. In the future, the identified data needs will be evaluated and prioritized, and a substance-specific research agenda will be proposed. 

A study of the dermal toxicokinetics of methyl parathion in female rats, sponsored by ATSDR, is being conducted at the University of Mississippi Medical Center. The principal investigator is Dr. Ing K. Ho, Department of Pharmacology and Toxicology, 500 North State Street, Jackson, Mississippi 39216-4505. 

ATSDR is conducting a health study to investigate the lasting health effects of methyl parathion exposure on children. In this study, ATSDR will be testing children in two states, Ohio and Mississippi. The principal Investigator is Dr. Rubina Imtiaz, ATSDR Division of Health Studies, 1600 Clifton Road, Atlanta, Georgia 30333. 

Methyl parathion has been illegally used inside the home to kill insects (ATSDR 1999 EPA 1999b). 

Methyl parathion is only for use on agricultural crops. The reports that methyl parathion has been illegally/improperly used inside homes to kill insects (ATSDR 1999 EPA 1999b) show that people in homes that are sprayed with methyl parathion may be exposed to dangerously high levels of methyl parathion. 

ATSDR has derived an intermediate-duration oral MRL of. 0007 mg/kg/day for methyl parathion based on a minimal LOAEL of 0.22 mg/kg/day for electrophysiological effects in the central and peripheral nervous systems in rats (Desi et al. 1998). 

EPA has derived an RfD of. 00025 mg/kg/day, based on a NOAEL of 0.025 for reduced hematocrit, erythrocyte counts, and hemoglobin (cholinesterase inhibition was also listed as a critical effect but the reason for this was not explained). This NOAEL appears to be from the same study as for the ATSDR chronic-duration oral MRL, although the study is referenced differently (IRIS 2001). 

ATSDR. 1989. Decision guide for identifying substance-specific data needs related to toxicological profiles. Atlanta, GA Agency for Toxic Substances and Disease Registry, Division of Toxicology. 

The Comprehensive Environmental Response, Compensation, and Liability Aet (CERCLA) [42 U.S.C. 9601 et seq ], as amended by the Superflind Amendments and Reauthorization Aet (SARA) [Pub. L. 99-499], requires that the Agency for Toxic Substances and Disease Registry (ATSDR) develop jointly with the US. Enviromnental Protection Agency (EPA), in order of priority, a list of hazardous substances most commonly found at facilities on the CERCLA National Priorities List (NPL) prepare toxicological profiles for each substance included on the priority list of hazardous substances and assure the initiation of a research program to fill identified data needs associated with the substances. 

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