Atropine dosages

Approximate age Approximate weight Number of Mark 1 kit autoinjectors to use Atropine dosage range (mg/kg) Pralidoxime dosage range (mg/kg)... 

Atropine sulfate, in conjunction with pralidoxime (2-PAM), can be administered as an antidote. Atropine should be administered by intravenous injection. Intramuscular injection can be used if IV injection is not possible. Atropine dosage Adults 0.4-2.0 mg... 

Relapse of cholinergic symptoms and unconsciousness has also been reported following dimethoate intoxication (Molphy and Rathus, 1964). A tractor driver with. subacute dicrotophos poisoning probably through both skin contact and Inhalation recovered from a moderate cholinergic cri.sis after atropine and pralidoxime treatment. He further improved when atropine dosage was tapered, but tm day 7 after the last exposure, he relapsed with prominent respiratory paralysis. Response to drug treatment, if any, was not mentioned. The ultimate outcome was favorable (Perron and Johnson, 1969),... 

The physician orders 0.4 mg of atropine The drug label reads 400 meg per 1 mL This dosage problem is solved by expanding the DA equation by adding one step to die equation. 

If pronounced bradycardia occurs, the primary heal til care provider may order emergency measures, such as die administration of IV atropine (see Chap. 25) or isoproterenol (see Chap. 22). Any sudden change in mental state should be reported to the primary health care provider immediately because a decrease in die dosage may be necessary. 

Compared with neostigmine,2 D.F.P. produced side effects more commonly and these arose in spite of administration of atropine (0-01 gr.) in an attempt to control the gut symptoms. There were no changes in liver, kidney or haemopoietic function ascribed to D.F.P. Asthma was considered a contra-indication to the use of D.F.P. It can thus be seen that D.F.P. in therapeutic dosage is a safe medicament.3... 

These statistics tends to belie the notion that children and the elderly, although somewhat more vulnerable, are extremely more likely to succumb to overdose. None of these data clearly establish the LD50 however, which is required to estimate the therapeutic ratio (LD50/ID50) for atropine. This ratio is an important key to making reasonable estimates of lethality for the other belladonnoids, since there are no BZ deaths (for example) from known dosage on which to base such estimates. 

Symptomatic treatment in parkinsonism for the purpose of restoring a dopaminergic-cholinergic balance in the corpus striatum. Antiparkinsonian agents, such as benzatropine (p. 188), readily penetrate the blood-brain barrier. At centrally equi-effective dosage, their peripheral effects are less marked than are those of atropine. 

Therapeutic measures include 1. administration of atropine in high dosage to shield muscarinic acetylcholine receptors and 2. reactivation of acetylcholinesterase by obidoxime, which successively binds to the enzyme, captures the phosphate residue by a nucleophilic attack, and then dissociates from the active center to release the enzyme from inhibition. 

Adults 50 to 100 mg. Hydroxyzine may potentiate concomitant narcotics and barbiturates reduce dosages accordingly. Atropine and other belladonna alkaloids may be given as appropriate. 

Difenoxin hydrochloride with atropine sulfate is not innocuous strictly adhere to dosage recommendations. Overdosage may result in severe respiratory depression and coma, possibly leading to permanent brain damage or death. 

Diphenoxylate w/Atropine Pediatric Dosage Age (years) Approximate weight Dosage (mL) (4 times daily)... 

Atropine, an alkaloid from Atropa belladonna, is the classical parasympatholytic compound. It competes with acetylcholine for the binding at the muscarinic receptor. Its affinity towards nicotinic receptors is very low, so that it does not interfere with the ganglionic transmission or the neuromotor transmission, at least in therapeutic dosages. However, in the central nervous system muscarinic receptor do play an important role and while atropine can penetrate the blood-brain barrier it exerts pronounced central effects. Atropine, like all other antagonists of the muscarinic acetylcholine receptor inhibit the stimulatory influence of the parasympathetic branch of the autonomous nervous system. All excretory glands (tear, sweat, salivary, gasto-intestinal, bronchi) are... 

Liquid oral antidiarrhoeals or any other dosage form for paediatric use containing diphenoxylate or atropine or belladonna including their salts and esters or metabolites, hyoscyamine or their extracts or their alkaloids. 

In the doses usually used, atropine has minimal stimulant effects on the CNS, especially the parasympathetic medullary centers, and a slower, longer-lasting sedative effect on the brain. Scopolamine has more marked central effects, producing drowsiness when given in recommended dosages and amnesia in sensitive individuals. In toxic doses, scopolamine, and to a lesser degree atropine, can cause excitement, agitation, hallucinations, and coma. 

Diphenoxylate (not more than 2.5 mg and not less than 0.025 mg of atropine per dosage unit, as in Lomotil)... 

Not more than 2.5 milligrams of diphenoxylate and not less than 25 micrograms of atropine sulfate per dosage unit. 

Dosages and routes of administration Diphenoxylate is used orally at initial doses of 10 mg, followed by 5 mg every 5 h. The standard formulation contains 1% atropine to inhibit parenteral misuse. 

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