Contra-indications

Tetracyclines are used as alternative dnigs in a variety of circumstances when the patient is unable to take the dnig of choice, eg, in patients allergic to penicillin (88,89). Tetracyclines are widely known to cause staining of teeth (and are therefore contra-indicated in children developing permanent teeth), photosensitivity, and, in the case of minocycline, vestibular toxicity. Details of these adverse effects and others associated with administration of tetracyclines have been comprehensively reviewed (96—101). 

The speciality chemical LifXTl (40% "CP) is used when calcium is contra-indicated,. such as in the. sanitation of hard water and in. some dairy applications. Some idea of the scale of these applications cati be gained from the following production figures which relate to the USA ... 

If the medicinal product (s) is currently licensed it is recommended that the current summary of product characteristics (Previously known as the data sheet) is consulted for appropriate contra indications, precautions and warnings. 

Compared with neostigmine,2 D.F.P. produced side effects more commonly and these arose in spite of administration of atropine (0-01 gr.) in an attempt to control the gut symptoms. There were no changes in liver, kidney or haemopoietic function ascribed to D.F.P. Asthma was considered a contra-indication to the use of D.F.P. It can thus be seen that D.F.P. in therapeutic dosage is a safe medicament.3... 

The information specified above in relation to dosage, method of use, side effects, precautions and contra-indications and any warning which is required to be included in advertisements, must be placed in such a position in the advertisement, that its relationship to the claims and indications for the product can be appreciated by the reader. 

There are various contra-indications for the clinical use of catecholamines. Hyperthyroidism goes together with an abnormal increase of sensitivity of the heart towards the sympathetic transmitters. An atherosclerotic compromised coronary circulation might not be able to sufficiently supply blood... 

Patients in whom haloperidol is contraindicated can be treated by intramuscular injection of benzodiazepines, but these can cause respiratory depression or respiratory arrest if given in too high a dose, are contra-indicated in patients with preexisting respiratory depression, and have no specific anti-psychotic effect. 

ACE-I is recommended for all the patients in this stage unless contra-indicated. If contraindications for ACE-I exist an ARB can be given. However, the routine combination of ACE-I, ARB and aldosterone antagonists is not to be recommended. 

Vasodilators can be considered as symptom relievers in this stage. However they are not the main agents for HF treatment because a reduction of mortality has not been established. A combination of hydralazine and a nitrate might be a reasonable strategy if HF symptoms are persistent despite ACE-I and -blocker combination therapy. If this ACE-I and -blocker combination is contra-indicated or is not tolerated. Vasodilators can be used without them. 

Simple antidiarrhoeals are generally contra-indicated, they do not help to reduce mucosal efflux, and may, by reducing colonic transit, predispose to megacolon development. Despite the strong association between non-smoking and the occurrence of ulcerative colitis nicotine patch treatment has shown little evidence of value. 

III.c.2.4. Contra-indications. The contra-indications for the application of single or combined drug therapy with IMNs are obvious. The inserted leaflets in the package of CyC, 5FU, MTX, and Oral MMF, and CyS are self-explanatory. 

This benefit comes at a cost of significant toxicity, particularly neuropathic, and more mature data are necessary to demonstrate the ultimate benefit of adjuvant therapies on improved overall survival. So far irinotecan plus 5-FU based therapy has produced disappointing results in adjuvant treatment. Despite the present lack of data addressing overall survival benefit, oxaliplatin plus 5-FU/leucovorin is widely recommended as the gold standard adjuvant therapy for stage 3 disease. For those whose medical fitness or other contra-indications preclude oxaliplatin based therapy 5-FU/leucovorin on a weekly or monthly schedule is recommended. Oral capecitabine for 6 months has recently been reported to be at least equivalent to 5-FU/leucovorin. 

Soomers AJ, Tack CJ. Ernstige lactaatacidose bij metfor-minegebruik bij een patient met contra-indicaties voar metformine. [Severe lactic acidosis due to metformin ingestion in a patient with contra-indication for metformin.] Ned Tijdschr Geneeskd 2001 145(2) 104—5. 

Houwerzijl EJ, Snoek WJ, van Haastert M, Holman ND. Ernstige lactaatacidose bij metforminegebruik bij een patient met contra-indicates voor metformine. [Severe... 

First, despite the widespread use of medications for pediatric sleep problems in clinical settings for both normal and developmentally delayed children, there are no medications approved by the Food and Drug Administration (FDA) for the treatment of difficulty initiating and/or maintaining sleep in the pediatric population. The sleep specialist should choose a treatment option that is matched to the patient s clinical situation, and is diagnostically driven rather than aimed at simply resolving the symptom. Examples of indications and contra-indications for use of hypnotics in pediatric insomnia are provided in the consensus statement [1],... 

Burke W. (1853) The Virginia Mineral Springs with Remarks on Their Use, The Diseases to Which They are Applicable, and in Which They are Contra-indicated. Ritchies and Dunnavant, Richmond, VA, 376pp. 

There have been additional recent reports of acute phosphate nephropathy following the use of OSPS (Table 2) [19, 31-33]. Similar to the majority of cases previously described, these patients appear to have taken OSPS at the correct dose and in the absence of clear contra-indications. Also similar to the previous reports, none of the patients have returned to normal renal function and no patient presented in the initial 24 hours with symptoms of hyperphosphatemia such as tetany or cardiac arrest. One case is of particular interest in that the pahent underwent renal biopsy both before and after exposure to OSPS [32]. The patient initially presented with nephrotic syndrome and normal renal function. Renal biopsy revealed membranous nephropathy (MN). In an effort to exclude a second-... 

Does not include contra-indications listed on the product label... 

Renal transplant pahents with hepatitis C seem to be especially susceptible to injury from IFNa. IFNa triggers renal graft rejection in a substantial number of patients, and is now considered contra-indicated in this setting [58, 59]. 

PanchmatiaKjJolobeOM. Contra-indications of Solpadol [letter]. Pharm 1993 251 73. 

The dosage, type or duration of application, new indications within the same therapeutic area as well as in Ccise of a restriction of the contra- indications, side effects or interactions with other products, as far as drugs are concerned which cire excluded from distribution outside of pharmacies. 

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