Diphenoxylate/atropine dosage

Diphenoxylate w/Atropine Pediatric Dosage Age (years) Approximate weight Dosage (mL) (4 times daily)... 

Liquid oral antidiarrhoeals or any other dosage form for paediatric use containing diphenoxylate or atropine or belladonna including their salts and esters or metabolites, hyoscyamine or their extracts or their alkaloids. 

Diphenoxylate (not more than 2.5 mg and not less than 0.025 mg of atropine per dosage unit, as in Lomotil)... 

Not more than 2.5 milligrams of diphenoxylate and not less than 25 micrograms of atropine sulfate per dosage unit. 

Dosages and routes of administration Diphenoxylate is used orally at initial doses of 10 mg, followed by 5 mg every 5 h. The standard formulation contains 1% atropine to inhibit parenteral misuse. 

Difenoxin, a diphenoxylate derivative, is also combined with atropine and has the same uses, precautions, and side effects. Marketed as 1-mg tablet, the adult dosage is 2 mg initially followed by 1 mg after each loose stool, not to exceed 8 mg/day. 

Diphenoxylate is a meperidine congener that is approved for the treatment of diarrhea (see Chapter 37). Diphenoxylate hydrochloride is available only in combination with atropine sulfate (LOMOTIL, Others). The recommended daily dosage of diphenoxylate for the treatment of diarrhea in adults is 20 mg in divided doses. Difenoxin (motofen), a metabolite of diphenoxylate, has actions similar to those of the parent compound. 

Difenoxin, the active metabolite of diphenoxylate (as described above), also is used as an antidiarrheal agent. Tablets contain 1 mg of difenoxin and 0.025 mg of atropine sulfate. Dosage, uses, and effectiveness are similar to those of diphenoxylate. 

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