Pralidoxime dosages

Approximate age Approximate weight Number of Mark 1 kit autoinjectors to use Atropine dosage range (mg/kg) Pralidoxime dosage range (mg/kg)... 

If exposure is through ingestion, the victim should seek medical help immediately. Emesis should not be induced. Initial management involves establishment of adequate ventilation and maintenance of adequate respiratory function. Activated charcoal therapy may be used to retard absorption from the gastrointestinal tract. Atropine sulfate alone, or in combination with pralidoxime chloride, can be administered as an antidote. Atropine is initially administered intravenously at a dosage of 1-2 mg kg every 5-10 min until... 

Atropine sulfate, in conjunction with pralidoxime (2-PAM), can be administered as an antidote. Atropine should be administered by intravenous injection. Intramuscular injection can be used if IV injection is not possible. Atropine dosage Adults 0.4-2.0 mg... 

Relapse of cholinergic symptoms and unconsciousness has also been reported following dimethoate intoxication (Molphy and Rathus, 1964). A tractor driver with. subacute dicrotophos poisoning probably through both skin contact and Inhalation recovered from a moderate cholinergic cri.sis after atropine and pralidoxime treatment. He further improved when atropine dosage was tapered, but tm day 7 after the last exposure, he relapsed with prominent respiratory paralysis. Response to drug treatment, if any, was not mentioned. The ultimate outcome was favorable (Perron and Johnson, 1969),... 

VI. Dosage and method of administration. For pralidoxime, the intravenous route... 

DuoDote has both the atropine and 2-PAM in the same syringe. DuoDote has only recently been made available to civilians. Some kits may also contain a diazepam or CANA injector (Figure S3.2). You must be able to identify the symptoms and signs that require use of the NAAK, select the appropriate dosage, and administer the atropine, pralidoxime, and diazepam as required. 

Pralidoxime (2-PAM) Pralidoxime is a commonly used oxime and is rccom-mended for all cases of moderate-to-severe nerve agent poisoning. The optimal dosage is dependent on the nerve agent, time since exposure and the cholinesterase activity of the victim, i here has been considerable experience with pralidoxime and other oximes over many years in the treatment of OP pesticide poisoning. 

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