Ganglionic transmission

Hirsutine. Hirsutine (58) shows ganglion-blocking activity in cat superior cervical ganglion preparation (331), and it has a long-lasting depressive effect (332). Hirsutine also inhibits the ganglionic transmission of the dog urinary bladder (353, 334). 

Atropine, an alkaloid from Atropa belladonna, is the classical parasympatholytic compound. It competes with acetylcholine for the binding at the muscarinic receptor. Its affinity towards nicotinic receptors is very low, so that it does not interfere with the ganglionic transmission or the neuromotor transmission, at least in therapeutic dosages. However, in the central nervous system muscarinic receptor do play an important role and while atropine can penetrate the blood-brain barrier it exerts pronounced central effects. Atropine, like all other antagonists of the muscarinic acetylcholine receptor inhibit the stimulatory influence of the parasympathetic branch of the autonomous nervous system. All excretory glands (tear, sweat, salivary, gasto-intestinal, bronchi) are... 

Pancuronium bromide (Pavulon) is a synthetic bis-quaternary agent containing a steroid nucleus (amino steroid), as denoted by the -curonium suffix. It is five times as potent as d-tubocurarine. Unlike d-tubocu-rarine, it does not release histamine or block ganglionic transmission. Like d-tubocurarine, it has a moderately long onset (2.9 minutes) and duration of action (110 minutes). Pancuronium and its metabolite are eliminated in the urine. 

E) Blockade of ganglionic transmission at sympathetic ganglia in the periphery... 

Doses of 2-PAM larger than 40 mg/kg, as well as TMB-4 and toxogonin, produced a temporary block of the cardiac response to vagal stimulation and of the nictitating membrane response to preganglionic, but not postganglionic, stimulation. There was transient hypotension due to block of ganglionic transmission.9,63,71... 

Depression of autonomic ganglionic transmission—certain quaternary ammonium compounds, such as tetraethylammonium salts. 

In 1978 we compared the structure activity requirements for the DA, (vascular DA) receptor with other putative DA receptors (1,4 )7 The limited SAR data available at that time supported the existence of at least two different DA receptors. DA-induced responses were divided into two categories on the basis of differences in agonist activity and potency series. The following phenomena appeared to be due to activation of DA2 receptors inhibition of norepinephrine release from the postganglionic sympathetic nerve inhibition of ganglionic transmission inhibition of prolactin release and emesis. Review of the current literature has not revealed exceptions to these correlations. 

Neurotransmission at both cholinergic and adrenergic synapses can be influenced by a variety of naturally occurring and synthetic drugs (Table 38.2). For example, ACh secretion is drastically reduced in the presence of botulinum toxin which contains proteases that cleave proteins vital to the process of exocytosis. Nicotine, one of the active ingredients in tobacco can mimic the effects of ACh and increase (or decrease at high doses) autonomic ganglionic transmission as well as that at the... 

Mclsaac, R. J., Koelle, G. B. Comparison of the effects of inhibition of external, internal and total acetylcholinesterase upon ganglionic transmission. J. Pharmacol. 

Maderdrut, J.L., Oppenheim, R.W. and Prevette, D. (1988) Enhancement of naturally occurring cell death in the sympathetic and parasympathetic ganglia of the chicken embryo following blockade of ganglionic transmission. Brain Res. 444 189-194. 

The primary pathway of cholinergic transmission in autonomic ganglia is similar to that at the neuromuscular junction of skeletal muscle. The initial depolarization is the result of activation of nicotinic ACh receptors, which are ligand-gated cation channels with properties similar to those found at the neuromuscular junction. Several secondary transmitters or modulators either enhance or diminish the sensitivity of the postganglionic cell to ACh. Ganglionic transmission is discussed in more detail in Chapter 9. 

Neural inhibition via autoreceptors and heteroreceptor i Ganglionic transmission CNS ... 

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