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Atropa species

Recent investigations of the regulation of the tropane alkaloid pathway in Datura, Hyoscyamus and Atropa species have focused on understanding the enzymes involved at the branch points and in investigating the role these play in regulating the flux into the different groups of products. [Pg.29]

Herbs claimed or shown to have antispasmodic effects, in vitro and/or in vivo, and to be antitussive, include Adhartoda vasica (malibar nut), Petasites hybridus (butterbur). Ephedra sinica (ephedra), Mentha peperita (peppermint), Atropa species (atropine). Curcuma longa (turmeric), Ocimum sanctum (basil), and Piper longum (pepper). [Pg.329]

By extraction of Solanacean drugs, especially Atropa belladonna, Hyoscyamus niger or other species. On careful extraction L-hyoscyamine is obtained first, which can be racemized to atropine by addition of alkali in ethanolic solution. [Pg.152]

The family Solanaceae consists of about 85 genera and 2800 species of plants, of which, 80 are of medicinal value in the Asia-Pacific region. Solanaceaeare well known for their parasympatholytic tropane alkaloids, such as hyoscyamine. Classic examples are Atropa belladonna L. (belladona herb, British Pharmacopoeia 1963), Datura stramonium L. (stramonium, British Pharmacopoeia, 1963), and the dried leaves and flowering tops of Hyoscyamus... [Pg.58]

A. Alkaloids 1. Belladonna-type solanaceous tropane alkaloids [Atropine (1), (—)-Hyoscyamine (2), Scopolamine ((—)-Hysoscine)(3)] Atropa belladonna L. (belladonna), Datura metel L., D. stramonium L. (jimson weed), Hyoscyamus niger L. (henbane), Mandragora officinarum L. (European mandrake), and other solanaceous species Anticholinergics (parasympatholytics)... [Pg.17]

Main alkaloid of Atropa belladonna Hyoscyamus niger several Datura species like suaveolens, sanguinea, Candida, metel, stramonium. [Pg.169]

The tropane alkaloids (—)-hyoscyamine and (—)-hyoscine are among the most important of the natural alkaloids used in medicine. They are found in a variety of solanaceous plants, including Atropa belladonna (deadly nightshade), Datura stramonium (thornapple) and other Datura species, Hyoscyamus niger (henbane), and Duboisia species. These alkaloids... [Pg.295]

Note The best-known antimuscarinic or anticholinergic drugs are the belladonna alkaloids. The major drugs in this class are atropine, hyoscyamine, and scopolamine. A number of plants belonging to the potato family (Solanaceae) contain similar alkaloids. Atropa belladonna (deadly nightshade), Hyoscyamus niger (henbane), Datura stramonium (jimsonweed or thorn apple), and several species of Scopolia also contain belladonna alkaloids. [Pg.203]

Tropine derivatives are typically found in certain highly poisonous Solanaceae species, most notably Atropa belladonna (deadly nightshade), Datura stramonium (thornapple), other Datura species, Duboisia myoporoides (corkwood elm), Hyoscyamus niger (henbane) and other Hyoscyamus species. Other sources include Convolvulus species (Convolvulaceae), Erythroxylum coca (coca), other Erythroxylum species (Erythroxylaceae) and Bruguiera species (Rhizophoraceae). [Pg.16]

Both untransformed (Hashimofo and Yamada, 1994) and transformed root cultures of Datura, Hyoscyamus, Atropa and Duboisia species (Robins and Walton, 1993) accumulate high levels of fhe fropane alkaloids, hyoscyamine and scopolamine (Fig. 2.3). These medically imporfanf fropane alkaloids present not only an interesting biochemical problem but also a realistic... [Pg.27]

The family Solanaceae is one of the important and interesting plant families. It may be classified into four groups based on their usefulness and chemical composition of alkaloids contained (1) Nicotiana spp. such as N. tabacum and N. rustica, which provide tobacco and contain nicotiana alkaloids such as nicotine and nomicotine (2) Hyoscyamus, Scopolia, Atropa, and Datura species, which are pharmacologically important and contain tropane alkaloids such as hyocyamine, scopolamine, and tropine (3) Solanum spp., which are sometimes the starting material for production of synthetic steroids for medical uses and which contain solanum alkaloids and (4) Capsicum, Solanum, and Lycoper-sicum species, which serve as foods and are alkaloid-free. [Pg.172]

Esters of tropic acid occur in nature and have a comparatively long history of use as drugs. Atropine (DL hyoscyamlne) and Its optical Isomers, the D and L-hyoscyamlnes, and scopolamine (L-hyoselne) and its optical Isomer, D -hyosclne, have been obtained from such plants as deadly nightshade (Atropa belladonna), jimsonweed (Datura stramonium), henbane (Hyoscyamus nlger), horsenettle (Solanum carollnense). and various species of Scopolla. nie L Isomers of both esters are more potent than the D Isomers. [Pg.131]

Hyoscyamine is found in Atropa belladonna (night-shade) and in several species of Hyoscyamus from which its name is derived. It is a crystalline compound, m.p. 108.5°, somewhat soluble in water but more readily in chloroform, alcohol or benzene. It is levo rotatory and yields crystalline salts more soluble in water than the base itself. With acids or alkalies hyoscyamine hydrolyzes as previously stated yielding tropine and tropic acid. [Pg.893]

Botanicals Atropa belladonna, Digitalis species, Colchicum, Rauwolfia serpentina, pyrrolizidine-containing plants (see separate monograph on pyrrolizidines)... [Pg.1612]

Two non-identified tropane alkaloids have been isolated from aerial parts of Scopolia tangutica. Correlation between total alkaloid content in Belladonna leaves and roots has been made. Regional differences in tropane alkaloid formation of atropine and scopolamine have been studied, using Atropa belladonna. Uptake of Vitavax-6 (10) via the C-labelled species was followed in Datura innoxia, a... [Pg.49]

Hyoscyamine and/or atropine occur in several plants of the family Solanaceae, such as species of Atropa, Datura, Hyoscyamus, Duboisia, Mandragora and Scopolia (20). In some of these plants e.g. belladonna and scopolia, hyoscyamine is the dominant alkaloid throughout the life cycle of the plant. In Datura stramonium, hyoscyamine is the principal alkaloid at the time of flower-... [Pg.173]

The combination of herbal sedatives such as valerian (V, officinalis), passion flower (Passiflora species), and anticholinergic Solanaceae (Atropa belladonna, Datura stromonium, Hyocyamus niger, and Mandragora offici-narum) with alcohol or antihistamines can potentiate the effects of antidepressants, antihistaminics, and antispasmodics, causing drowsiness and obtunding the ability to use machinery (D Arcy, 1993 De Smet et al., 1996). [Pg.287]

CAS 51-55-8. C17H23N03. An alkaloid obtained from species of Atropa, Datura, or Hyoscyamus. [Pg.109]


See other pages where Atropa species is mentioned: [Pg.677]    [Pg.128]    [Pg.677]    [Pg.128]    [Pg.68]    [Pg.821]    [Pg.47]    [Pg.48]    [Pg.388]    [Pg.25]    [Pg.41]    [Pg.161]    [Pg.258]    [Pg.259]    [Pg.341]    [Pg.173]    [Pg.328]    [Pg.685]    [Pg.80]    [Pg.120]    [Pg.35]    [Pg.369]    [Pg.307]    [Pg.320]    [Pg.321]    [Pg.190]    [Pg.107]    [Pg.13]    [Pg.1]    [Pg.361]   
See also in sourсe #XX -- [ Pg.329 ]




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