Critical Assessment CASP

CASP stands for Critical Assessment of techniques for protein Structure Prediction. 

Moult J, T Hubbard, K Fldelis and J T Pedersen 1999. Critical Assessment of Methods of Protein Structure Prediction (CASP) Round III. Proteins Structure, Function and Genetics Suppl. 3 2-6. 

J Moult, T Flubbard, SFI Bryant, K Fidelis, JT Pedersen. Critical assessment of methods of protein structure prediction (CASP) Round II. Proteins Suppl 1 2-6, 1997. 

The strongest verification for a 3D-protein model comes from the experimental 3D-structure. This is the objective of the Critical Assessment of Techniques for Protein Structure Prediction, CASP ( http //predic tioncenter.org), where the structural models are made in advance of the experimental structure of a particular protein. 

CASP (Critical Assessment on Structure Prediction) 89 catalysis 55,66... 

Protein-structure prediction methods are routinely compared and contrasted in a public competition called the Critical Assessment of Techniques for Protein Structure Prediction (CASP). These large-scale events allow for a comparison of the state-of-the-art tools and algorithms on a variety of target sequences. The results of each event are scrutinized. There have been five such events thus far, with CASP5 being the most recent (31). 

CASP Critical assessment of methods of protein structure prediction... 

Currently, methods of structure prediction from sequence perform poorly. The results of the biannual CASP experiment (Critical Assessment of techniques for protein Structure Prediction see http //predictioncenter.llnl. gov/) are equivocal to say the least. A recent report on the improvements of aligning target sequences to a structural template (67) indicates that over the last four CASP competitions there was no significant improvement in quality in this key step in the prediction process. Alignment remains the major source of error in all models based on less than 30% se-... 

Another forum for testing homology modeling methods has been the ongoing series of CASP meetings (for Critical Assessment of Protein Struc-... 

In CASP II (Critical Assessment of Methods of Protein Structure Prediction Round II), a new prediction section on protein-ligand docking was introduced [154]. Several groups participated and submitted up to three models for some of the seven protein-ligand complexes (see [155-158] for reports). For each target, the 3D structure of the protein and the 2D structure of the ligand was given to the participants. All complexes were unpublished before the submission deadline. 

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