Aspirin rheumatic fever

An important class of compounds that have members from both prescription and over-the-counter drugs are those that relieve pain. Aspirin is a common type of analgesic. It is also an antipyretic, that is, it lowers abnormally high body temperatures. A third use is in reducing inflammation caused by rheumatic fever and rheumatoid arthritis. Salicylic acid has been known for its analgesic properties since the early 1800s. Kolbe and... 

The sahcylates are useful in the treatment of minor musculoskeletal disorders such as bursitis, synovitis, tendinitis, myositis, and myalgia. They may also be used to relieve fever and headache. They can be used in the treatment of inflammatory disease, such as acute rheumatic fever, rheumatoid arthritis, osteoarthritis, and certain rheumatoid variants, such as ankylosing spondylitis, Reiter s syndrome, and psoriatic arthritis. However, other NS AIDS are usually favored for the treatment of these chronic conditions because of their lower incidence of GI side effects. Aspirin is used in the treatment and prophylaxis of myocardial infarction and ischemic stroke. 

The effect of Salix alba L. (white willow) is largely owed to a glycoside, salicin. Salicin is antipyretic and analgesic and has been used in the treatment of rheumatic fever (salicilin tablets British Pharmaceutical Codex, 1949). In 1893, Felix Hofmann, a chemist working for the Bayer chemical company in Germany, first synthesized acetyl-salicylic acid, the acetylated form of salicin. Aspirin is one of the most commonly used pharmaceuticals containing salicin. Today, the main commercial sources of salicin are Salix fragilis and Salix purpurea (Salicaceae), which are native to Eurasia. 

Acute rheumatic fever is treated with anti-inflammatory agents such as aspirin. Corticosteroids are reserved for those patients with severe carditis who do not respond to or are unable to take salicylates. 

Aspirin is employed for mild to moderate pain of varied origin but is not effective for severe visceral pain. Aspirin and other NSAIDs have been combined with opioid analgesics for treatment of cancer pain, where their anti-inflammatory effects act synergistically with the opioids to enhance analgesia. High-dose salicylates are effective for treatment of rheumatic fever, rheumatoid arthritis, and other inflammatory joint conditions. 

Aspirin reduces the leukocytosis associated with acute rheumatic fever. When given on a long-term basis, it also reduces the hanoglobin level and the hematocrit. Aspirin use can cause reversible hypoprothrombinemia by interfering... 

It is generally used for the reduction of fever and the relief of pain. It also possesses anti-inflammatory actions similar to aspirin. It is recommended in acute rheumatic fever and in the symptomatic therapy of gout. 

No drugs have been a more faithful companion to man throughout his history than salicylates, the forebears of aspirin. About 3,500 years ago the Ebers Papyrus recommended the application of a decoction of leaves of myrtle to the abdomen and back to get rid of rheumatic pains. Hippocrates championed the juices of the poplar tree and willow bark to treat fever and labor pains. These plants and trees are abimdant in compounds derived from salicylic acid, which gets its name from them (in Latin salix is a willow tree). For thousands of years on all continents they have helped to... 

Benoral benorylate. benorilate benorylate. benorylate [ban] (benorilate [inn] paracetamol acetylsallcylate BenoraP ) is an aspirin-paracetamol ester, and these two pharmacologically active constituents are released systemically at different rates. It has cyclooxygenase inhibitor, nsaid analgesic, antiinflammatory and antirheumatic activity. It is used orally, particularly to treat the pain of rheumatic disease and other musculoskeletal disorders, as well as to treat fever, benoxaprofen [ban, inn, usan] (Opren ) is one of the propionic acid series of CYCLOOXYGENASE INHIBITORS with nsaid ANALGESIC. ANTIINFLAMMATORY and ANTIPYRETIC activity also effective for psoriasis. It was withdrawn due to adverse drug reactions. 

Two herbs that have been used for centuries to treat headaches, fever, sore muscles, and rheumatism are white willow bark and meadowsweet, commonly described as Nature s aspirin. White willow bark Salix alba) contains salicin, a glycoside of salicylic acid. Once in the stomach, the salicin hydrolyzes into salicylic acid, which is the active principle for reducing pain and fever. White willow bark has been mentioned in ancient Egyptian, Assyrian, Greek, and Chinese manuscripts, and it was used to treat pain and fever by the ancient physicians Galen, Hippocrates, and Dioscorides. Native Americans used it for headaches, fever, sore muscles, rheumatism, and chills. In the mid-1700s, it was used to treat malaria. Salicin was isolated and identified in the early 1830s, but it was not conclusively shown to reduce the aches and soreness of rheumatism until 1874. White willow bark is recommended for headaches, backache, nerve pain, toothache, and injuries. 

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