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Gastric residence time

P. Mojaverian and P. H. Vlasses, Effects of gender, posture, and age on gastric residence time of an indigestible solid Pharmaceutical considerations, Pharm. Res., 5, 639 (1988). [Pg.690]

Itoh, T., Higuchi, T., Gardner, C.R. and Caldwell, L. 1986. Effect of particle size and food on gastric residence time of nondisintegrating solids in beagle dogs. J. Pharm. Pharmacol. 38 801-806. [Pg.761]

As a result, if dissolution from formulations is studied exclusively under low pH conditions, the formulators are likely to be in for a rude shock when the results come back from the pharmacokinetic studies—poor and highly variable absorption is the order of the day for drugs that have been formulated without an eye to robustness of the release from the dosage form as a function of pH. Instead, it is recommended that a formulation be sought that can release the drug even when there is not enough acid in the stomach to provide a sufficient boost to the solubility or when the gastric residence time is short. [Pg.214]

Examination of the results on the basis of where the majority of pellets were situated (Table 2) shows that food increased the gastric residence time in each volunteer by 2-10 h. The entry of... [Pg.127]

Mojaverian P, Ferguson PK, Vlasses PH, Rood ML Jr, Oren A, Fix JA, Caldwell LJ, Gardner C. Estimation of gastric residence time of the Heidelberg capsule in humans effect of varying food composition. Gastroenterology, 1985 89 392-397. [Pg.100]

Mojaverian, P., Rocci, M. L., Conner, D. P., et al. Effect of food on the absorption of enteric-coated aspirin Correlation with gastric residence time. Clin. Pharmacol. Ther. 41 11-17, 1987. [Pg.196]

The relationship between gastric residence time (GRT) and the variability in aspirin absorption from enteric-coated tablets has also been evaluated with the Heidelberg capsule [59], The study design was a single dose crossover study with men and women, fasted and fed. In addition to pH monitoring, plasma concentrations of salicylic acid and salicyluric acid in plasma and urine were measured. GRT was significantly delayed in the fed state, and women had longer GRT compared with men. [Pg.29]

Mojaverian P (1996) Evaluation of gastrointestinal pH and gastric residence time via the Heidelberg Radiotelemetry Capsule Pharmacological application. Drug Development Research 38 73-85... [Pg.13]

The optimization of prolonged gastric residence time (GRT) should be done in the light of dissolution time required to achieve complete... [Pg.1253]

See other pages where Gastric residence time is mentioned: [Pg.238]    [Pg.238]    [Pg.52]    [Pg.59]    [Pg.59]    [Pg.656]    [Pg.203]    [Pg.53]    [Pg.759]    [Pg.106]    [Pg.213]    [Pg.213]    [Pg.125]    [Pg.128]    [Pg.70]    [Pg.70]    [Pg.71]    [Pg.71]    [Pg.72]    [Pg.74]    [Pg.114]    [Pg.187]    [Pg.189]    [Pg.189]    [Pg.195]    [Pg.198]    [Pg.714]    [Pg.285]    [Pg.38]    [Pg.1234]    [Pg.1291]    [Pg.1294]    [Pg.1850]    [Pg.1859]   
See also in sourсe #XX -- [ Pg.1291 ]



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