Aspirin cancer chemoprevention

Kune GA. Colorectal cancer chemoprevention aspirin, other NSAID and COX-2 inhibitors. Aust NZ JSurg 2000 70 452 155. 

Cancer Chemoprevention Epidemiological studies suggested that frequent use of aspirin is associated with as much as a 50% decrease in the risk of colon cancer and similar observations have been made with other cancers. NSAIDs have been used in patients with familial adenomatous... 

Sample, D., Wargovich, M., Fischer, S.M., Inamdar, N., Schwartz, P., Wang, X. et al., A dose-finding study of aspirin for chemoprevention utilizing rectal mucosal prostaglandin E2 levels as a biomarker. Cancer Epidemiol Biomarkers Prev., 11,275-279, 2002. 

Rao. K.V., Detrisac, C.J., Steele, V.E., Hawk. E.T.. Kelloff, G.J.. and McCormick. DP. (1996) Differential Activity of Aspirin. Ketoprofen and Sulindac as Cancer Chemopreventive Agents in the Mouse Urinary Bladder. Carcinogenesis 17, 1435-1438. 

Lynch snggests that CRC is an excellent model for investigating cancer prevention throngh means of secondary approaches snch as polypectomy for removal of precursor colonic adenomas as well as primary (chemoprevention) strategies. Attention was appropriately called to the manner in which the regular use of aspirin and other NSAIDs has led to a reduction in risk of CRC. Herein, a possible mechanism from this beneflt relates to the mentioned decreased prostaglandin production,... 

Suleiman, S., Rex, D.K., and Sonnenberg, A., Chemoprevention of colorectal cancer by aspirin a cost-effectiveness analysis. Gastroenterology, 122, 78-84, 2002. 

Williams, J.L., Nath, N., Chen, J., Hundley, T.R., Gao, J., Kopelovich, L., Kashfi, K., and Rigas, B. (2003). Growth inhibition of human colon cancer cells by nitric oxide (no)-donating aspirin is associated with cyclooxygena.se-2 induction and beta-catenin/t-cell factor signahng, nuclear factor-kappab, and no synthase 2 inhibition Implications for chemoprevention. Cancer Res. 63, 7613-7618. 

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