Aspirin anti-inflammatory properties

Acetaminophen is a pain reliever similar to aspirin, but it does not have aspirin s anti-inflammatory properties—or its undesirable effects... 

Like oxycodone, oxycodone with aspirin is used to treat moderate to severe pain. The aspirin provides additional pain relief and anti-inflammatory properties not found in oxycodone alone. For some types of pain, these medications may be a better choice than oxycodone alone, particularly if pain is accompanied by significant inflammation, swelling, and stiffness. The aspirin component also may be especially beneficial if pain is accompanied by fever. 

Like oxycodone with aspirin, oxycodone with acetaminophen combines a powerful pain reliever with an additional pain reliever and a fever-reducer. However, unlike aspirin, it does not have anti-inflammatory properties, so it may not be the best medication if a patient s pain is accompanied by inflammation, swelling, and stiffness. 

Although equivalent to aspirin as an effective analgesic and antipyretic agent, acetaminophen differs in that it lacks anti-inflammatory properties. It does not affect uric acid levels and lacks... 

Correct answer = C. Among the NSAIDs, aspirin is among the worst for causing gastric irritation. Aspirin is an effective analgesic and is used to reduce muscle pain. It also has antipyretic actions so that it can be used to treat fever. Because of its anti-inflammatory properties, aspirin is used to treat pain related to the inflammatory process, for example, in the treatment of rheumatoid arthritis. Low doses of aspirin also decrease the incidence of transient ischemic attacks. 

Aspirin, or acetylsalicylic acid, is the most well known member of a group of compounds called salicylates. Although aspirin was first used in medicine for its analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory properties, today it is commonly used as an antiplatelet agent in the treatment and prevention of heart attacks and strokes. Aspirin is a synthetic compound it does not occur in nature, though some related salicylates are found in willow bark and meadowsweet blossoms. 

Sometimes, chemists prepare molecules that do not occur in nature (although they may be similar to those in nature), because these molecules have superior properties to their naturally occurring relatives. Aspirin, or acetylsalicylic acid (Section 2.7), is a well known example. Acetylsalicylic acid is prepared from phenol, a product of the petroleum industry, by a two-step procedure (Figure 7.23). Aspirin has become one of the most popular and widely used drugs in the world because it has excellent analgesic and anti-inflammatory properties, and it is cheap and readily available. 

Ibuprofen was developed by researchers at the Boots Company, a British drug manufacturer, in the early 1960s. Those researchers had found that the anti-inflammatory property of aspirin was due to the presence of a carboxylic acid (-COOH) group in the compound. They searched for other carboxylic acids that might have similar properties and, after testing more than 600 compounds, discovered that ibuprofen met that criterion. It was twice as effective as... 

It is prepared by the condensation of two moles of salicylic acid in the presence of thionyl chloride. It has antipyretic, analgesic and anti-inflammatory properties similar to those of aspirin. It is employed in the treatment of rheumatoid arthritis and other rheumatic disorders. 

Aspirin has anti-inflammatory properties due to its ability to decrease arachidonic acid metabolites, especially prostaglandins, by inhibiting cyclooxygenase enzymes COX-1 and COX-2. COX inhibition, especially of COX-2, is the key biochemical target of the... 

Salicylates are widely used for their analgesic and anti-inflammatory properties. They are found in a variety of prescription and over-the-counter analgesics, cold preparations, and topical keratolytic products (methyl salicylate), and even Pepto-Bismol (bismuth subsalicylate). Eiefore the introduction of child-resistant containers, aspirin overdose was one of the leading causes of accidental death in children. Two distinct syndromes of intoxication may occur, depending on whether the exposure is acute or chronic. 

Sun, Y. R, S. F. Oh et al. 2007. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. 

Sun Y.-R, Oh S. R, Uddin J., Yang R., Gotlinger K., Campbell E., Colgan S. R, Petasis N. A., Serhan C. N. 2007. Resolvin D1 and its aspirin-triggered 17R epimer Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. Journal ofBioloeical Chemistry. 282(13) 9323-9334. 

NSAIDs have analgesic and anti-inflammatory properties and are, therefore, widely used for the treatment of both minor and more severe pain and for the management of swelling and joint inflammation. Some NSAIDs also possess antipyretic activity and are, therefore, useful for the treatment of fever. Specihcally, NSAIDs available over the counter such as aspirin and ibuprofen are heavily used for self-medication of a host of... 

As previously mentioned, the action of anti-inflammatory steroids stems from their ability to prevent the release of arachidonic acid. There is another class of therapeutic agents that also exhibit anti-inflammatory properties, but their mode of action is entirely different. These drugs are called non steroidal anti-inflammatory drugs, or NSAIDs, and the most common examples are aspirin, ibuprofen, and naproxen. 

Of course, none of this was known in 1897 when aspirin was first synthesised or indeed even earlier where it had long been recognised that extracts of willow bark had anti-inflammatory properties. Aspirin soon entered into clinical use and it was followed by other compounds such as indomethacin. The first adverse effects to become apparent were those on the gastrointestinal system. 

Aspirin is a rather simple molecule that has important analgesic, anti-inflammatory, and antipyretic properties. It is known how aspirin works it is an irreversible inhibitor of COX. In fact, there are three human COX enzymes more about this follows below. 

Acetaminophen differs from the nonsteroidal anti-inflammatory agents described in that it is devoid of anti-inflammatory and antirheumatic properties. It was recently shown that acetaminophen, like aspirin, inhibits cyclooxygenase action in the brain and is even stronger than aspirin. On the other hand, the mechanism of analgesic action of acetaminophen is not fully clear, since it acts poorly on peripheral cyclooxygenase. 

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