Aspidosperma quebracho bianco

Floriani has recently examined bark from Aspidosperma quebracho bianco Schlecht f. pendulas Speg, in which he found the known alkaloids, quebrachine (yohimbine) and aspidospermine, as well as Hesse s aspidosamine, C2gH2g02N2, and a new base, aspidospermicine, Ci Hj ON, l-SHjO (1938). Hartmann and Schlittler have shown that the alkaloid vallesine from Vallesia glabra (Apocynaceae) is aspidospermine, and this has been confirmed by Deulofeu et aJ. who have also found it in V. dichotoma. Later Schlittler and Rottenberg by chromatographic analysis of the mother liquors of aspidospermine isolated a second alkaloid for which they used the old name Vallesine (1948). ... 

Rhazinilam 3 is an axially chiral phenyl-pyrrole compound which was first isolated from Melodinus australis (F. Muell.) Pierre [53]. It has also been found in other Apocynaceae such as Rhazya stricta Decaisne [54,55], Aspidosperma quebracho-bianco Schlecht. [56,57], Leuconitis eugenifolia A. DC [58,59] and Kopsia singapurensis [60]. More recently, (-)-rhazinilam was isolated from intergeneric somatic hybrid cell cultures of two Apocynaceae, Rauvolfia serpentina Benth. Ex Kurz and Rhazia stricta Decaisne [61]. 

By the use of mass spectroscopy coupled with deuterium labeling, eburnamonine, (iso (eburnamine, and ebumamenine have been shown to exist (stereochemistry not specified) in Rhazya stricta Decaisine, and ebumamenine itself in Aspidosperma quebracho bianco Schlecht (19). The obtention of ebumamenine from Pleiocarpa species is described in Section III. 

Alkaloid Akuammidine Aspidosperma quebracho-bianco, Picralima nitida (Apocvnaceae) (indole) [seed] 5.6a O-R ligand (p) [0.6], (8) [2], (k) [9] [opioid agonist Naloxone antagonized MVD relaxation]... 

Aspidosperma quebracho-bianco, Catharanthus roseus, Picralima nitida (Apocynaceae) [seed]... 

Botanical origin Strophanthus Kombe Strophanthus hispidus Strophanthus hispidus Apocynum cannabinum Aspidosperma Quebracho bianco... 

Aspidospermine one indole alkaloid was isolated from bark of Aspidosperma quebracho-bianco, displaying antimalaiial activity on Plasmodium falciparum (29). 

From the bark of Aspidosperma quebracho bianco. Six alkaloids identified quebra-chine, aspidospermine, aspidospermatine, as-pidosamine, hypoquebrachine. Quebrachine is said to be poisonous with effects like those of strychnine. 

Aspidosperma. Quebracho. Dried bark of Aspidosperma quebracho-bianco Schlecbt., Apocynaceae. Habit. Argentina. Constit. 0.3 -1.4% alkaloids—aspidospermine, aspidospermatine, aspidosamine, quebrachinc. quebrach-amine. hypoquebrachine. quebrachol. qucbrachit tannin. 

Quebracho (cortex). The bark of the quebracho tree, Aspidosperma quebracho-bianco (Apocynaceae), a large tree (up to 20 m high), indigenous to the west of South America. The bark contains ca. 1% monoter-penoid indole alkaloids such as yohimbine, aspido-spermine, quebrachamine. The Aspidosperma alkaloids are structurally related to the Catharanthus alkaloid vindoline. Quebracho bark contains over 25 different alkaloids of widely differing types. ... 

The main alkaloid of this plant material was isolated in 1896 by Spiegel [1] and named yohimbine.The alkaloid was the same as one obtained previously from Aspidosperma quebracho-bianco (Apocynaceae) [2]. Isoyohimbine and allo-yohimbine, possessing structures similar to that of yohimbine, were also isolated from P. yohimba [3,4]. Isoyohimbine, based on the studies of Warnat [3], is known as a-yohimbine. 

Isol. from cultured cells of Aspidosperma quebracho-bianco (Apocynaceae). Amorph. powder. 

Bark may contain up to 6 % total alkaloids, of which 10-15 % is yohimbine [120]. Concentrations of yohimbine in commercial products ranged from less than 0.1 to 489 parts per million (ppm) compared with 7,089 ppm in the authentic material. The alkaloid yohimbine also is obtained from Aspidosperma quebracho-bianco and Rauwolfia serpentina [121]. Its interest outside the African continent was first recorded in Germany, where yohimbine, the main alkaloid of the drug and also known as aphrodine, quebrachine, or corynine, was isolated for the first time by Spiegel in 1896 [130]. Recent advancements in the development of yohimbe-based... 

Aspidosperma quebracho bianco (Apocynaceae) is a tall tree that grows wild in Argentina, Brazil, and Chile. The bark is called quebracho bark or white quebracho , and contains tannins and alkaloids. It is used in folk medicine as an antipyretic and diuretic and as a treatment for pertussis and asthma. 

Biemann K, Friedmann-Spiteller M, Spiteller G 1961 An investigation by mass spectrometry of the alkaloids of Aspidosperma quebracho-bianco. Tetrahedron Lett 485-492... 

Schnoes H K, Burlingame A L, Biemann K 1962 Application of mass spectrometry to structure problems. The occurrence of eburnamenine and related alkaloids in Rhazya stricta and Aspidosperma quebracho bianco. Tetrahedron Lett 993 - 999... 

Aspidospermidine, one of the simplest of Aspidosperma alkaloids containing a pentacyclic ring system, was isolated from Aspidosperma quebracho bianco and other Aspidosperma species. Aspidosperma is a genus of flowering plant in the family Apocynaceae. The alkaloids aspidosper-mine were first synthesized by Stork and Dolfini in 1963. " Since then the compound has had many extensive investigations, and more than 30 research groups have synthesized... 

Biemann K, Spiteller-Friedmann M, Spiteller G. Application of mass spectrometry to stmcture problems. X. Alkaloids of the bark of Aspidosperma quebracho bianco. J. Am. Chem. Soc. 1963 85(5) 631-638. 

Wiedemann [130] used samples of redwood Sequoia sempervirens), balsa Ochroma pyramidale/lagopus), quebracho bianco Aspidosperma quebracho-bianco) and beech wood (Fagus spec.) to determine the mechanical properties of wood by means of TMA and DSC. Flexure measurements as depicted in Figure 23 show different, highly reproducible onset temperatures for breakdown in the chosen samples from the very light balsa wood to the very hard South American quebracho bianco and - for comparison - bamboo. TMA together with DSC results indicates that such breakdowns take place only after the complete decomposition of cellulose. 

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