Rhazia stricta

Rhazinilam 3 is an axially chiral phenyl-pyrrole compound which was first isolated from Melodinus australis (F. Muell.) Pierre [53]. It has also been found in other Apocynaceae such as Rhazya stricta Decaisne [54,55], Aspidosperma quebracho-bianco Schlecht. [56,57], Leuconitis eugenifolia A. DC [58,59] and Kopsia singapurensis [60]. More recently, (-)-rhazinilam was isolated from intergeneric somatic hybrid cell cultures of two Apocynaceae, Rauvolfia serpentina Benth. Ex Kurz and Rhazia stricta Decaisne [61]. 

It was first shown, using C-labelled mevalonate, that ajmalicine [162], catharanthine [162] and vindoline [162-165] in Catharanthus roseus as well as other alkaloids in Catharanthus roseus [162], Rauwolfia serpentina [166] and Rhazia stricta [162] gave the appropriate specific incorporation consistent with a monoterpenoid origin for the C q (or Cg) fragment additional to the trypt-amine-derived [167, 168] moiety. This work was rapidly followed by independent demonstrations [169-172] that [2- C]geraniol and its pyrophosphate, which is to be regarded as the prototype monoterpenoid in Nature, are incor-... 

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