Picralima nitida

The alkaloids discussed in the succeeding paragraphs occur in the seeds of Picralima nitida Th. and H. Durand (syn. P. klaineana Pierre), which is widely but sparsely distributed throughout tropical Africa. The seeds of this plant are used by the West African natives as a specific for malaria, and as an antipyretic (1, 2). The first chemical examination of Picralima was conducted by Clinquart, who obtained a crystalline alkaloid, mp 242°-243°, and a second, amorphous base (3, 4). Various color reactions of these specimens were described, but beyond this no attempts were made to characterize them completely. The alkaloids were shown to occur chiefly in the seeds, but they are also present in the leaves and bark (3, 4). 

Alkaloid Akuammidine Aspidosperma quebracho-bianco, Picralima nitida (Apocvnaceae) (indole) [seed] 5.6a O-R ligand (p) [0.6], (8) [2], (k) [9] [opioid agonist Naloxone antagonized MVD relaxation]... 

Aspidosperma quebracho-bianco, Catharanthus roseus, Picralima nitida (Apocynaceae) [seed]... 

---