Asiaticosides

Centella asiatica (L.) Urb. Ji Xue Cao (Gotu kola) (whole plant) Asiaticoside, madecassoside, brahmoside, brahmissoside, glucoside asiaticoside, sitosterol, tannin, vallarine, pectic acid, resin.33-450-510 Antibacterial, lower blood pressure, antipyretic, diuretic, detoxicant. 

N.A. Triterpenoid, saponins, oleic acid, vellarin, hydrocotyline, sitosterol, asiatic, madecassic, madasiatic acids, asiaticoside.99 100-115 116311 Treat skin disease, leprosy, antipyretic, detoxicant, diuretic, antirheumatic, mild diuretic, sedative, and peripheral vasodilator. 

Asiaticoside Asoryl-ketone Asparagic acid Asparagine... 

Saponins (e.g., asiaticoside, 17) are widely distributed in plants as well as in some lower marine animals and possess a broad range of biological activities [62a], Examples of acylation of these complex molecules have been reported by different authors. For instance, the regioselective esterification of 17 by CalB was quite remarkable, and only the 4" -0-acetate (17a) was isolated in 59% yields [66]. 

Asiaticoside (= Asiatic acid triglycoside) Centella asiatica (Apiaceae) PKA (190) [promotes wound healing]... 

Awareness of this problem led to the rapid development of new TCA peel formulas between 1990 and 2000. One of the first solutions put forward was the New Peel combination of TCA and Mikuda complex. The soft Peel formulation used asiaticosides and ginsenoids, glycerol, urea (carbamide), sorbitan monolaurate and methyldibromo-glutaronitrile, among other ingredients. Easy TCA , Unideep and Only Touch Peel (OTP) provided another answer to the problem these stabilized solutions consist of a base solution to which a determined quantity of 50% m/m TCA is added. There are no complicated calculations to be performed, the directions for use state precisely what volume of 50% m/m TCA solution should be added to the base solution to make up the Easy TCA , Unideep and OTP solutions, which provide peels to the basal layer, the papillary dermis and the reticular dermis, respectively. 

Asiaticoside, an ursane-type triterpene saponin from Centella asiatica has been shown to stimulate skin human fibroblasts collagen I synthesis in vitro. By comparison asiaticoside and asiatic acid, it seemed that the sugar moiety was not necessary for this activity [223]. 

Fig. 8A Centellae herba (2) is characterized by the ester saponins asiaticoside (T2) and made-cassoside", a mixture of asiaticoside A and 13 (T3) seen as brown-violet to violet zones in the R, range 0.2-0.35 and the blue aglycone zone at R, — 0.85.

Depending on the drug origin (e.g. India or Africa), asiaticoside and/or madecassoside (asiaticoside A and B) are pre.sent in various concentrations. 

Asiaticosid Asiaticoside Ba 2742 Blastoestimulina BRN 0078195 Centelase Dermatologico EINECS 240-851-7 Emdecassol Madecassol NSC 166062. A proprietary preparation extract of Ceniella asiatica in an ointment used for skin protection. Powder mp = 230-233° insoluble in H2O soluble in EtOH, C5H5N [a]S = -14° (EtOH). Rona Laboratories,... 

Mahato, S.B. Sahu, N.P. An improved process for the isolation of asiaticoside, useful as an antileprotic agent from Centella asiatica, Indian patent filed, 1993. 

Asiaticoside. Saponin-like triterpene glycoside C48H78O, Mr 959.14, mp. 235-238°C, [aln -14° (C2H5OH) from the leaves of the Asian marsh pennywort, Centella asiatica Hydrocotyle asiatica, Apia-ceae). A. shows antibiotic activity against Gram-positive bacteria and mycobacteria and has a wound-healing effect. 

Baek, M. Rho, Y.S. Kim, D.H. Column-switching high-performance liquid chromatographic assay for determination of asiaticoside in rat plasma and bile with... 

Sikareepaisan P, Suksamrarn A and Supaphol A (2008), Electrospun gelatin fiber mats containing a herbal-CeuteZZa asiatica-exVcact and release characteristic of asiaticoside . Nanotechnology, 19(1), 1-10. DOI 10.1088/0957-4484/19/01/015102. 

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