Aryl hydrocarbon receptor agonists

Safe, S. (2001). PCBs as aryl hydrocarbon receptor agonists. In PCBs Recent Advances in Experimental Toxicology and Health Effects. L.W. Robertson and L.G. Hansen (Eds.) Lexington University of Kentucky Press, 171-178. 

Vorderstrasse, B., Cundiff, J., and Lawrence, B.P., Developmental exposure to the potent aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs the cell-mediated immune response to infection with influenza A virus, but enhances elements of innate immunity, J. Immunotoxicol., 1, 103, 2004. 

Sprague-Dawley rats exposed to a mixture of aryl hydrocarbon receptor agonists. Toxicol Sci 86 175-184. 

Wassenberg DM, Di Guilio RT. 2004. Synergystic embryotoxicity of polycyclic aromatic hydrocarbons aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus. Environ Health Perspect 112 1658-1664. 

Zhang S, Qin C, Safe SH. Flavonoids as aryl hydrocarbon receptor agonists/ antagonists Effects of structure and cell context. Environ Health Perspect 2003 111 1877-82. 

Hahn, M.E. and K. Chandran. Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and planar chlorobiphenyls. Arch. Biochem. Biophys. 329 163-174, 1996. 

Stegeman, J., M. Hahn, R. Weisbrod, B. Woodin, J. Joy, S. Najibi and R. Cohen. Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells. Mol. Pharmacol. 47 296-306, 1995. 

White, R.D., D. Shea and J.J. Stegeman. Metabolism of the aryl hydrocarbon receptor agonist 3,3, 4, 4 tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. Drug Metab. Dispos. 25 564-572, 1997. 

Bello, S.M., D.G. Franks, J.J. Stegeman and M.E. Hahn. Acquired resistance to aryl hydrocarbon receptor agonists in a population of Fundulus heteroclitus from a marine Superfund site in vivo and in vitro studies on the induction of xenobiotic-metabolizing enzymes. Toxicol. Sci. 60 77—91, 2001. 

Liu, H., M. Santostefano, and S. Safe (1994). 2-Phenylphenanthridinone and related compounds Aryl hydrocarbon receptor agonists and suicide inactivators of P4501A1. Arch. Biochem. Biophys. 313,206 214. 

Barron M. G., Heintz R., and Rice S. D., Relative potency of PAHs and heterocycles as aryl hydrocarbon receptors agonists in fish, Mar. Environ. Res., 58, 95-100, 2004. 

Species difference in the regulation of cytochrome P450 2S1 lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126. Xenobiotica 41 1031-1043... 

Wassenberg, D.M. Di Giulio, R.T. 2004. Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with Cytochrome P4501A inhibitors in Fundulus heteroclitus. Environmental Health Perspectives, v.ll2, p. 1658-1664. 

The aryl hydrocarbon receptor (ARH-R or dioxin receptor) is activated by xenobiotics such as 2,3,7,8-tetrachlorodibenzo-j6-dioxin with resultant adverse effects. The activated receptor binds to a xenobiotic-responsive element with the consequent activation of the transcription of particular genes. Cell cycle progression is inhibited by naturally occurring and synthetic flavonoids at concentrations at which they act as agonists of the ARH-R. 

Aryl hydrocarbon receptor (ARH-R) Alkaloid Tryptanthrine Strobilanth.es cusia (Acanthaceae), 11.2A 11.2Aa ARH-R agonist (COX-2) [i iNOS... 

Ciolino HP, Wang TTY, Yeh GC. 1998. Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differen-... 

M.K. Bunger, and C.A. Bradfield (2000). ARA9 modifies agonist signaling through an increase ip cytosolic aryl hydrocarbon receptor. J. Biol. Chem. 275, 6153-6159. 

A cell-based assay that has attracted a lot of attention in this regard is Dioxin-Responsive Chemically Activated LUciferine gene expression (DR-CALUX), a technique that detects all aryl hydrocarbon receptor (AHR) agonists (Murk 1996). This approach uses genetically modified... 

Chen, L, Safe, S., and Bjeldanes, L., Indole-3-carbinol and diindolyhnethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells, Biochem. Pharmacol, 51, 1069-1076, 1996. 

Willett, K., M. Steinberg, J. Thomsen, T.R. Narasimhan, S. Safe, S. McDonald, K. Beatty and M.C. Kennicutt. Exposure of killifish to benzo[a ]pyrene comparative metabolism, DNA adduct formation and aryl hydrocarbon (Ah) receptor agonist activities. Comp. Biochem. Physiol. 112B 93—103, 1995. 

Chaloupka K, Harper N, Krishnan V, et al. 1993. Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists. Chem-Bio Interact 89 141-158. 

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