Artificial endocrine pancreas

M. Shichiri, Y. Yamasaki, N. Hakui, and H. Abe, Wearable artificial endocrine pancreas with needle-type glucose sensor. Lancet 2, 1129-1131 (1982). 

The application of an artificial endocrine pancreas (AEP=Biostator) with feedback control could be useful in the clinical management of unstable diabetics (Ohno et al., 1983). Former early closed-loop devices were large bedside machines (Pfeiffer et al., 1974) with only limited application for long-term use. More recent research has developed small glucose sensors which, however, have had only preliminarily testing for clinical application. External insulin pumps must be further miniaturized and technical failure... 

Nishida, K., Shimoda, S., Ichinose, K., Araki, E., and Shichiri, M. (2009) What is artificial endocrine pancreas Mechanism and history. World Journal of Gastroenterology, 15 (33), 4105-4110. 

Hadjidakis DJ, Halvatsiotis PG, loannou YJ, Mavrokefalos PJ, Raptis SA. The effects of the somatostatin analogue SMS 201-995 on carlx>hydmte hcxneostasis of insulin-dependent diabetics as assessed by the artificial endocrine pancreas. Di(AetesRes Clin Pract( 9BZ) 5,91-... 

APPLICATION OF MPC COPOLYMERS FOR IMPLANTABLE GLUCOSE SENSOR OF ARTIFICIAL ENDOCRINE PANCREAS... 

This chapter will review current activities and proposed research related to the development of artificial organs and organ-assist devices. While we will focus on the human liver, the discussion is applicable to other organs. The pancreas and the endocrine functions of the kidney follow the same basic path — the culturing of cells on a scaffold. The cells, of course, must function as they do in a natural uncompromised slate while the scaffold provides a permanent or temporary template on which the cells attach and proliferate. 

Mascini M., Fortunati S., Moscone D., Palleschi G., Massi-Benedetti M. and Fabietti P. (1985) An L-lactate sensor with immobilized enzyme for use in in vivo studies with an endocrine artificial pancreas. Clin. Chem., 31, 451-453. 

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