Arrhythmias bradycardia

These drugs are used cautiously in patients witii hypertension, epilepsy, cardiac arrhythmias, bradycardia, recent coronary occlusion, and megacolon. The safely of diese drugs has not been established for use during pregnancy (Pregnancy Category C), lactation, or in children. 

Uses Rapid conversion of AF/artmal fluto Action Class III antiarrhythmic Dose Adults >60 kg. 0.01 mg/kg (max 1 mg) IV inf over 10 min may repeat x 1 <60 kg Use 0.01 mg/kg (ECC 2005 D/C cardioversion preferred) Caution [C, -] Contra w/ class I/III antiarrhythmics (Table VI-7) QTc >440 ms Disp Inj SE Arrhythmias, HA Interactions t Refractory effects W7 amiodarone, disopyra-mide, procainamide, quinidine, sotalol t QT int val W7 antihistamines, antidepressants, erythromycin, phenothiazines, TCAs EMS Use antihistamines w/ caution, may T QT interval OD May cause increased repolarization leading to arrhythmias, bradycardia, hypotension leading to cardiac arrest symptomatic and supportive... 

Severe hyperkalemia may produce arrhythmias, bradycardia, and ECG changes (tented T waves, widening QRS complex, and ST segment depression). These may proceed to cardiac standstill or ventricular fibrillation. 

Metoprolol Block 3i > 32 Lower HR and BP reduce renin may be safer in asthma Angina pectoris hypertension arrhythmias Bradycardia fatigue vivid dreams cold hands... 

Already, we know the physiological response to chronic GPCR activation is cardiac arrhythmia bradycardia or tachycardia depending on whether the G-protein is stimulatory (Gees) or inhibitory (Gcd, GPy) (Redfern et al. 1999 Gehrmann et al. 2002 Hardt et al. 2002 Zhai et al. 2005 Nishizawa et al. 2006). A stimulatory G-protein results in an increase of intracellular calcium, while an inhibitory... 

Acute digoxin poisoning causes initial nausea and vomiting and hyperkalaemia because inhibition of the Na, K" -ATPase pump prevents intracellular accumulation of potassium. The ECG changes (see Table 24.1) of prolonged use of digoxin may be absent. There may be exaggerated sinus arrhythmia, bradycardia and ectopic rhythms with or without heart block. 

The cardiovascular manifestations of hypocalcemia result in electrocardiographic changes characterized by a prolonged QT interval and symptoms of decreased myocardial contractdity often associated with congestive heart failure. Both acute and chronic hypocalcemia may result in a reversible syndrome characterized by acute myocardial failure or refractory congestive heart failure. Other cardiovascular manifestations include arrhythmias, bradycardia, and hypotension that is unresponsive to fluid and pressor administration. ... 

The paralysis affects the striated muscles primarily, excluding the respiratory muscles and those of the face. The muscles of the lower limbs are attacked first, then those of the arms, the trunk, and the neck. Physical signs are non existent between the crises of paralysis, but the tendon reflexes and muscle excitability to electrical stimulation are often abolished during a crisis. Occasionally, the myocardium is also paralyzed, and the cardiomegaly, arrhythmias, bradycardia, and hypertension observed in patients with periodic paralysis may result from cardiac muscle paralysis. The gastrointestinal symptoms (vomiting, nausea, and flatulence) in these patients are sometimes attributed to involvement of the smooth muscle of the gastrointestinal tract. 

Systemic reactions to local anesthetics including cardiac arrhythmia, bradycardia, cardiovascular collapse, increased defibrillator threshold, and heart block can occur. 

Arrhythmias Originating in the Sinus Node Sinus bradycardia Sick sinus syndrome Sinus tachycardia Disorders of Impulseformation ... 

Normal rhythmic activity is the result of the activity of the sinus node generating action potentials that are conducted via the atria to the atrioventricular node, which delays further conduction to the His-Tawara-Purkinje system. From the Purkinje fibres, action potentials propagate to the ventricular myocardium. Arrhythmia means a disturbance of the normal rhythm either resulting in a faster rhythm (tachycardia, still rhythmic) or faster arrhythmia (tachyarrhythmia) or slowed rhythm (bradycardia, bradyarrhythmia). 

Supraventricular bradycardia is treated by implantation of a pacemaker device or has been treated pharmacologically with atropine. Supraventricular paroxysmal tachycardia is treated with aj marine or praj marine. Supraventricular tachyarrhythmias or AV reentrant arrhythmia typically can be terminated using adenosine. 

Cardiac-changes in pulse rate or rhythm electrocardiographic changes, such as bradycardia, tachycardia, premature ventricular contractions, bigeminal (two beats followed by a pause), or trigeminal (three beats followed by a pause) pulse. Other arrhythmias (abnormal heart rhythms)also may be seen. 

Administration of oxytocin may result in fetal bradycardia, uterine rupture, uterine hypertonicity, nausea, vomiting, cardiac arrhythmias, and anaphylactic reactions. Serious water intoxication (fluid overload, fluid volume excess) may occur, particularly when the drug is administered by continuous infusion and the patient is receiving fluids by mouth. When used as a nasal spray, adverse reactions are rare. 

Irritation of the vein used for administration, tingling, a metallic or chalky taste, and heat waves may occur when calcium is given IV Rapid IV administration (calcium gluconate) may result in bradycardia, vasodilation, decreased blood pressure, cardiac arrhythmias, and... 

III Life-threatening symptoms collapse, tachycardia or bradycardia, arrhythmias, bronchospasm... 

Norepinephrine 2-100 pg/minute Seconds to minutes Bradycardia, arrhythmia Alpha-1, beta-1, increased CO, decreased SVR... 

---