Array technology

Brocklehurst, K.R. and Morby, A.P., Metal-ion tolerance in Escherichia coli Analysis of transcriptional profiles by gene-array technology, Microbiology, 146 (9), 2277-2282, 2000. 

Stevens P.W., Wang C.H.J., Kelso D.M., Immobilized particle arrays coalescence of planar- and suspension-array technologies, Anal Chem 2003 75 1141-1146. 

FitzGerald, S.P., Lamont, J.V., McConnell, R.I., and Benchikh, E.O. (2005) Development of a high-throughput automated analyzer using biochip array technology. Clin. Chem. 51(7), 1165-1176. 

Although virtually all drug targets are protein based, the inference that protein expression levels can be accurately (if indirectly) detected/measured via DNA array technology is a false one, as ... 

Focal plane detectors are used primarily to detect ions separated in space by, for example, magnetic sector analyzers (see Section 2.2.2). The objective of an ideal focal plane detector is to simultaneously record the location of every ion in the spectrum. In many ways the photoplate (see Section 2.3.1) is the original focal plane detector, but it has today been more or less replaced with designs that rely on EM detectors (see Section 2.3.3). A common arrangement is to allow the spatially disperse ion beams simultaneously to impinge on an MCP (see Section 2.3.3.2). The secondary electrons generated by the ion impacts then strike a one- or two-dimensional array of metal strips and the current from the individual electrodes is recorded. A tutorial on the fundamentals of focal plane detectors is found in Reference 283. Reference 284 provides a relatively recent review of MS detector-array technology. 

J. H. Barnes IV and G. M. Hieftje. Recent Advances in Detector-Array Technology for Mass Spectrometry. Int. J. Mass Spectrom., 238(2004) 33-46. 

Nolan JP, Sklar LA (2002) Suspension array technology evolution of the flat-array paradigm. Trends Biotechnol 20 9-12... 

Evaluation of Efficacy and Systemic Toxicity in the Mouse Using Array Technology... 

Using array technology in pharmacogenomics, efficacy and systemic toxicity can be evalnated for the improvement of the design and development of preclinical vaccines. Methods of applying pharmacogenomics in the evaluation of efficacy and adverse events dnring clinical development of vaccines are also discnssed. 

Novagen (ProteoPlex ), S S (FAST Quant), BioSource (Cartesian Array ), and BD Biosciences (BD Clontech Ab Microarrays) have introduced or will soon introduce protein microarray slide formatted products in which antibodies are directly immobilized. Beckman Coulter s protein array products for performing micro-ELlSAS in standard 96-well plate formats are based upon the self-assembly (by hybridization) of oligonucleotide-antibody conjugates to complementary oligonucleotides arrayed in individual wells. HTG s protein array technology was described previously. 

While the Schena papers (1995 and 1996) served as first demonstrations of cDNA microarray fechnology, it was clear that further refinements were necessary in order to realize the full pofenfial of the microarray. Arraying technology was in its infancy and suffered from inconsistency in uniform spotting, making it difficult to compare slides. Refinements in labeling and detection were also needed. 

While the monitoring of infectious biological agents (bacteria and viruses) using DNA probe array technology is well known, many of the applications involve identification of allele-specific targets. Conversely, examining... 

This book picks up the array technology journey from the mid-1990s with the introduction of microarray-based gene expression analysis. The global analysis of genes by microarrays has provided a fresh and exciting view of the cellular process. More importantly, it enabled others to consider similar utility in various "omic" fields. Hence, we have witnessed the emergence of protein arrays to address proteomics. 

Robert (Bob) Matson, Ph.D., is a senior staff scientist in the Advanced Technology Center at Beckman Coulter, Inc., Fullerton, California. He has been involved in the development of both nucleic acid and protein array-based technology for the past 13 years. His initial introduction to array technology began in collaboration with Sir Edwin Southern in developing an in situ oligonucleotide array synthesis platform for the corporation. Later work by Dr. Matson and his research team produced some of the first plastic microplate-based microarrays. Beckman Coulter recently launched the pi te based upon the microplate "array of arrays" concept. 

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