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Synthesis aromatic

Although bromomethylation is a less common reaction than chloromethylation, the methodology is the same, so the reagents will be CH2=0 and HBr, with methanol as solvent. This is a Friedel-Crafts reaction. A range of conditions could be employed the most successful was PhCOCl, AICI3, CSj solvent. [Pg.582]

I have used MCPBA, but most peracids would be fine. Bromobenzene is then converted into phenyl-magnesium bromide using magnesium in dry ether and opens the epoxide to give the required product  [Pg.582]

Chlorine is ortho,para-Airectin, nitro is mete-directing. So we must nitrate first. Our reagents are cone. HNOj/conc. HjSO for the first step, followed by Clj/FeClj for the second step. The halogen carrier is essential because the nitro group is very deactivating. [Pg.583]

We will need first to convert the aniline into the diazonium salt. This then undergoes an azo coupling with unreacted aniline. [Pg.584]

Moving on to the second type of problem, let s try this one. PROBLEM 13.17 [Pg.586]


C ( propyl) N phenylmtrone to N phenylmaleimide, 46, 96 semicarbazide hydrochloride to ami noacetone hydiochlonde, 46,1 tetraphenylcyclopentadienone to diphenyl acetylene, 46, 44 Alcohols, synthesis of equatorial, 47, 19 Aldehydes, aromatic, synthesis of, 47, 1 /3-chloro a,0 unsaturated, from ke tones and dimethylformamide-phosphorus oxy chloride, 46, 20 from alky 1 halides, 47, 97 from oxidation of alcohols with dimethyl sulfoxide, dicyclohexyl carbodumide, and pyndimum tnfluoroacetate, 47, 27 Alkylation, of 2 carbomethoxycyclo pentanone with benzyl chloride 45,7... [Pg.120]

Alcohols, conversion to alkyl halides with triphcnylphosphine-halogen adducts, 48, 53 synthesis of equatorial, 47, 19 Aldehydes, aromatic, synthesis of, 47, 1... [Pg.68]

By this strategy, anilines 299 can be obtained from aromatics ketones 300 (equation 104). The Beckmann rearrangement/hydrolysis sequence is able to replace an acyl group by an amine and has been used in aromatic synthesis to attach directly nitrogen atoms to aromatic rings, providing an alternative strategy to the classical nitration/reduction sequence. [Pg.416]

The six-carbon chain of ManNAc 6-P can be extended by three carbon atoms using an aldol-type condensation with a three-carbon fragment from PEP (Eq. 20-7, step c) to give N-acetylneuraminic acid (sialic acid).48 Tire nine-carbon chain of this molecule can cyclize to form a pair of anomers with 6-membered rings as shown in Eq. 20-7. In a similar manner, arabi-nose 5-P is converted to the 8-carbon 3-deoxy-D-manno-octulosonic acid (KDO) (Fig. 4-15), a component of the lipopolysaccharide of gram-negative bacteria (Fig. 8-30), and D-Erythrose 4-P is converted to 3-deoxy-D-arafrmo-heptulosonate 7-P, the first metabolite in the shikimate pathway of aromatic synthesis (Fig. 25-1).48a The arabinose-P used for KDO synthesis is formed by isomerization of D-ribulose 5-P from the pentose phosphate pathway, and erythrose 4-P arises from the same pathway. [Pg.1136]

In another recent development in aromatic synthesis, the Bergman cydization [7] is beginning to be exploited for preparative purposes. This process has been studied for many years because of its importance with regard to the biological action of several marine antitumor antibiotics such as calicheamicin [58] and because of its interesting reaction mechanism [8]. Now, more and more synthetic applications are beginning to be reported in the literature [59]. [Pg.186]

A further example concerns the verification of the theory of aromaticity. Synthesis of the eight-membered analog of benzene, cyclooctatetraene 71 (Scheme 1.22), accomplished in 1911 by Willstadter, was an outstanding achievement in its own right. Even more important was elucidation of the nonaromatic character of this molecule. This finding provided a powerful impact on the studies aimed at the elaboration of a more consistent explanation of aromaticity phenomena. [Pg.33]

Since aryl halides are fairly cheap reagents, there has been less recent emphasis (see Section 3 below) on the development of aryl relative to that of alkyl C-H bond activation [13-17]. However, the manufacture of aryl halides is not an environmentally friendly process and thus the future of bulk aromatic synthesis may he in the direct activation of C-H bonds. For example, the formation of ben-zaldehyde from the insertion of CO into a C-H bond of benzene is a recent development in this area [17]. [Pg.3]


See other pages where Synthesis aromatic is mentioned: [Pg.572]    [Pg.64]    [Pg.801]    [Pg.254]    [Pg.818]    [Pg.912]    [Pg.126]    [Pg.345]    [Pg.801]    [Pg.1332]   
See also in sourсe #XX -- [ Pg.254 ]




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Alcohols aromatic, synthesis

Aldehydes aromatic, direct synthesis

Aldehydes aromatic, synthesis by formylation

Aldehydes, aromatic, synthesis

Aldehydes, aromatic, synthesis from alkyl halides

Aliphatic—aromatic liquid-crystalline polymers, synthesis

Alkanes aromatic, synthesis

All-benzenoid Polycyclic Aromatic Hydrocarbons Synthesis, Self-assembly and Applications in Organic Electronics

Amines aromatic, synthesis by Chichibabin

Application of Electrocyclic Ring Closure in Aromatic Synthesis

Aromatic Kolbe-Schmitt synthesis

Aromatic Polyesters synthesis method

Aromatic Substitution Approaches to Synthesis

Aromatic Substitution by Electrophiles (Lewis Acids, E 2 Electrophilic Substitutions in Syntheses of Benzene erivatives

Aromatic acids synthesis

Aromatic amino acid decarboxylase dopamine synthesis

Aromatic amino acid decarboxylase serotonin synthesis

Aromatic amino acids, synthesis

Aromatic carboxylic acids, synthesis

Aromatic compounds biaryls, synthesis

Aromatic compounds synthesis

Aromatic detergent synthesis

Aromatic direct synthesis

Aromatic erythrinan alkaloids synthesis

Aromatic esters, synthesis

Aromatic fluorides, synthesis

Aromatic heterocycle synthesis benzimidazoles

Aromatic heterocycle synthesis indoles

Aromatic heterocycle synthesis pyridazines

Aromatic heterocycle synthesis pyridines

Aromatic heterocycle synthesis pyridones

Aromatic heterocycle synthesis quinolines

Aromatic hydrocarbons, synthesis

Aromatic ketones, synthesis

Aromatic natural products biomimetic synthesis

Aromatic nitramines, synthesis

Aromatic nitriles synthesis

Aromatic nucleophilic substitution synthesis

Aromatic poly synthesis

Aromatic ring, synthesis

Aromatic structures electrochemical synthesis

Aromatic substitution, carbene synthesis

Aromatic sulfonic acids, synthesis

Aromatic sulfoxides, synthesis

Aromatic synthon synthesis

Aromatic systems, synthesis

Aromaticity aromatic detergent synthesis

Aromaticity, organic synthesis

Aromatics synthesis from methanol

Azapentalenes, aromatic synthesis

Azides aromatic, synthesis

BORSCHE - BEECH Aromatic aldehyde synthesi

BORSCHE-BEECH Aromatic Aldehyde Synthesis

Basic Principles Synthons and Reagents Synthesis of Aromatic Compounds

Bis-p-phenylene-34-crown-10 synthesis—a receptor for n-electron-deficient aromatics

Bisphenol in synthesis of aromatic condensation

Carbocyclic synthesis aromatic compounds

Carboxylic acid anhydrides: aliphatic aromatic, synthesis

Carboxylic acid halides: aliphatic, synthesis aromatic

Chloroplasts aromatic amino acid synthesis

Chorismate mutase, aromatic amino acid synthesis

Cyclopropa-aromatics, synthesis

DAHP synthase, aromatic amino acid synthesis

Diene syntheses with aromatic polycycles

Electrophilic aromatic substitution reactions asymmetric synthesis

Electrophilic aromatic synthesis

Electrophilic aromatic synthesis strategies

Fluorinated aromatics, synthesis

Formals, aromatic synthesis

Formation of Aromatic Carboxylic Acids The Kolbe-Schmitt Synthesis

Heterocycle synthesis aromatic

High-Pressure Synthesis of Aromatic Polyimides

Multicomponent Synthesis of Annelated Thiopyranones by Coupling-Addition-Nucleophilic Aromatic Substitution Sequence

Organic synthesis aromatic compounds

Oxadiazoles, aromaticity ring syntheses

PAHs (polycyclic aromatic synthesis

Pictet-Spengler reactions synthesis of aromatic alkaloids

Poly , aromatic synthesis procedure

Polycyclic aromatic compounds synthesis

Polycyclic aromatic hydrocarbons , synthesis

Polycyclic aromatics, synthesis

Polycyclic aromatics, synthesis cyclodehydration

Polyformals, aromatic synthesis

Polyketide aromatic compounds synthesis

Polynuclear aromatic compounds synthesis

Radical-nucleophilic aromatic substitution heterocyclic synthesis

Regioselective Synthesis of Disubstituted Aromatic Compounds

SYNTHESIS OF SUBSTITUTED AROMATIC COMPOUNDS

Shikimate 3-phosphate aromatic amino acid synthesis

Shikimate dehydrogenase, aromatic amino acid synthesis

Some classic aromatic heterocycle syntheses

Special Topic Biological Synthesis of Aromatic Rings Phenylalanine

Steel, P. J., Aromatic Biheterocycles: Syntheses

Steel, P. J., Aromatic Biheterocycles: Syntheses Structures, and Properties

Strategies for Aromatic Synthesis Order of Group Substitution

Synthesis and Chemistry of Polycyclic Aromatic Hydrocarbons with Curved Surfaces Buckybowls

Synthesis and Reactivities of Aromatic Oxides

Synthesis aromatic polyesters

Synthesis aromatic substitution

Synthesis continued) nucleophilic aromatic substitution

Synthesis from aromatic aldehydes

Synthesis from aromatic ketones

Synthesis heterocyclic aromatic compounds

Synthesis of Aliphatic and Aromatic Amines

Synthesis of Aromatic Aldehydes (Formylation Reactions)

Synthesis of Aromatic Compounds

Synthesis of Aromatic Heterocycles

Synthesis of Aromatic Ketones (Friedel-Crafts Acylation)

Synthesis of Benzene Derivatives Electrophilic Aromatic Substitution

Synthesis of Functionalized Aryl Boranes by Catalytic Aromatic C-H Borylation

Synthesis of Saturated and Aromatic Ketones

Synthesis of aromatic aldehydes

Synthesis of aromatic carboxylic acids

Synthesis of aromatic ketones

Synthesis via coupling aromatic diazonium salts with carbon nucleophilic 4 atom fragments

Synthesis via nucleophilic aromatic

Synthesis with aromatic substitution reactions

Synthesis, trisubstituted aromatic

The Palladium-Catalyzed Synthesis of Aromatic Heterocycles

The Total Synthesis of Aromatic Steroids

The synthesis of an aromatic polyamide

Trifluorovinyl aromatic ether synthesis

Trisubstituted aromatic compound synthesis

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