Basic Principles Synthons and Reagents Synthesis of Aromatic Compounds

Background Needed for this Chapter References to Clayden, Organic Chemistry Electrophilic aromatic substitution chapter 22. (Electrophilic Aromatic Substitution) Nucleophilic aromatic substitution chapter 23 (Electrophilic Alkenes). [Pg.7]

Reduction chapter 24 (Chemoselectivity Selective Reactions and Protection). [Pg.7]

You already know that disconnections are the reverse of known reliable reactions so you should not make a disconnection unless you have such a reaction in mind. In designing a synthesis for the local anaesthetic benzocaine 1, we see an ester group and know that esters are reliably made from some derivative of an acid (here 2) and an alcohol (here ethanol). We should disconnect the C-0 ester bond. From now on we will usually write the reason for a disconnection or the name of the forward reaction above the arrow. [Pg.7]

The sign for a disconnection on a molecule is some sort of wiggly line across the bond being disconnected. You can draw this line in any way you like within reason. The reaction arrow is the implies arrow from logic. The argument is that the existence of any ester implies that it can be made from an acid and an alcohol. [Pg.7]

Organic Synthesis The Disconnection Approach. Second Edition Stuart Warren and Paul Wyatt 2008 John Wiley Sons, Ltd [Pg.7]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...