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Synthesis continued nucleophilic aromatic substitution

Nitrogen heterocycles continue to be valuable reagents and provide new synthetic approaches such as NITRONES FOR INTRAMOLECULAR -1,3 - DIPOLAR CYCLOADDITIONS HEXAHYDRO-1,3,3,6-TETRAMETHYL-2,l-BENZISOX AZOLINE. Substituting on a pyrrolidine can be accomplished by using NUCLEOPHILIC a - sec - AM IN O ALKYL ATION 2-(DI-PHENYLHYDROXYMETHYL)PYRROLIDINE. Arene oxides have considerable importance for cancer studies, and the example ARENE OXIDE SYNTHESIS PHENANTHRENE 9,10-OXIDE has been included. An aromatic reaction illustrates RADICAL ANION ARYLATION DIETHYL PHENYLPHOSPHONATE. [Pg.234]

The first thianthrene dication (32) has been isolated. Work on the thianthrene cation radical (33) continues. Its reaction with aliphatic amines yielded the sulphimides (34 X = NR) phenols and aromatic amines were attacked in the pflra-position to afford (34 X = / -HOCeH4 or p-R2NC H4), and enolizable ketones yielded the j8-keto-sulphonium salts (34 X = CHR COR ). The latter compounds reacted with nucleophiles Y to give the a-substituted ketones YCHR COR, and might prove to be useful intermediates for their synthesis. Reinvestigation of the kinetics of the reaction of (33) with phenol and with anisole has provided evidence which appears to disprove the disproportionation mechanism postulated earlier for these reactions. [Pg.338]


See other pages where Synthesis continued nucleophilic aromatic substitution is mentioned: [Pg.256]    [Pg.162]    [Pg.499]    [Pg.463]    [Pg.591]    [Pg.156]    [Pg.513]    [Pg.60]    [Pg.1]    [Pg.172]    [Pg.13]    [Pg.338]    [Pg.338]    [Pg.5]    [Pg.589]    [Pg.86]    [Pg.27]    [Pg.17]    [Pg.338]   


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Aromatic nucleophiles

Aromatic nucleophilic substitution synthesis

Aromatic substitution nucleophilic

Aromatic synthesis

Continuous synthesis

Nucleophile aromatic substitution

Nucleophilic aromatic

Nucleophilic aromatic substitution nucleophiles

Nucleophilic substitution synthesis

Nucleophilic substitution—continued

Substitution synthesis

Synthesis aromatic substitution

Synthesis continued)

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