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Ares-Serono

Rebif (rhIFN-P-la) Ares Serono Relapsing-remitting MS... [Pg.224]

Luveris (rhLH) Ares-Serono Some forms of infertility... [Pg.321]

Rebif (rh IFN- S-IA) Ares Serono Relapsing/remitting multiple sclerosis... [Pg.209]

Rebif (rh IFN-/l-la, produced in CHO cells) Ares-Serono Relapsing/remitting multiple sclerosis 1998 (EU), 2002 (USA)... [Pg.503]

Schering Plough Schering AG Berlex Laboratories and Chiron Biogen Ares Serono... [Pg.356]

Annual Report 1995, ARES-SERONO Follicle Stimulating Hormone. [Pg.757]

Chao W, Rudd CJ, Costa E, Jong L, Hobbs PD, Lehmann JM, Pfahl M, Lombardo A, Ely KA, Quick T et al (1995) Effects of receptor-selective retinoids on epidermal cells in the presence of the tumor promoter 12-0-tetradecanoylphorbol-13-acetate. American Association of Cancer Research Special Conference, Mechanism of Action of Retinoids, Vitamin D and Steroid Hormones. Whistler, British Columbia, Canada Bollag W, Apfel C, LeMotte P (1995) Retinoids Achievements, prospectives and future goals. In S Waxman (ed.) Challenges in Modem Medicine, VoL 10. Proceedings of the 6th Conference on Differentiation Therapy. Ares Serono Symposia Publications, Rome, 285-302... [Pg.192]

Two of the more recent such approvals are that of Ovitrelle and Luveris. Ovitrelle is the trade name given by Serono to its recombinant hCG-based product. The producer is an engineered CHO cell line that has been co-transfected with the genes coding for both the hCG a- and P-subunits. Downstream processing entails a combination of several chromatographic and ultrafiltration steps and the final product is presented in freeze-dried form. Each vial of product contains 285 fig of active substance (hCG) and the product has been assigned a 2 year shelf-life. It is reconstituted with water for injections (WFI) immediately before use. [Pg.343]

A recombinant IFN-P, IFN-pia (Rebif Serono and Avonex Biogen) is produced for commercial use in Chinese hamster ovary (CHO) cells. A synthetic mutant produced in bacteria has a substitution of serine for cysteine at amino acid 17, yielding IFN-pib Betaseron Berlex). Both IFN-pia and IFN-pib are approved by the FDA for treatment of multiple sclerosis (MS) and have shown comparable biological activity (see Section 7.3). In vivo IFN-a2 and IFN-alb show comparable biological activity as well as similar side effects [54,55]. However, IFN-P is eliminated faster, resulting in no detectable serum peak levels [56]. The clinical consequence of this is not known. Objective responses, whether partial or complete tumor regression, have been documented in patients with carcinoma of the breast, hairy-cell leukemia, and non-small-cell lung cancer [57,58]. [Pg.166]

Many recombinant proteins that are not antibodies are also on the market for distinct applications (see Chapter 16). Examples are factor VIII for hemophilia A treatment (Bayer, 1993, produced from BHK cells), erythropoietin as an anti-anemic agent (Amgen, 1989, produced from CHO cells) and /1-interferon for the treatment of multiple sclerosis (Biogen and Serono, 1996, produced from CHO cells). [Pg.6]

IFN-y9 is sold commerdally under the trade names Betaseron (Berlex, Schering AG), Rebif (Serono) and Avonex (Biogen) [25] for the treatment of multiple sclerosis. The latter is administered intramuscularly once per week, while the former two are administered 3 times per week s.c. Several groups have explored PEGylation as an approach to improving the pharmacokinetics profile of IFN-/ . [Pg.1404]

Therapeutic proteins are normally made in the human body under certain conditions, and synthetic versions of these proteins that are made in labs can be used as medicine. For example, human cells make a protein called interferon in response to viral infections, but synthetic interferon can also be used to treat multiple sclerosis. Two synthetic forms of interferon-1 (3, Rebif, which is made in CHO cells by EMD Serono, and Avonex, also made in CHO cells by Biogen Idee, serve as treatments for multiple sclerosis. Alefacept (brand name Amevive), which is made by AsteUas Pharma, is a fusion protein that blocks the growth of specific T cells (immune cells). No such protein exists in the human body, but alefa-cept is used to treat psoriasis and various cancers. [Pg.178]

See other pages where Ares-Serono is mentioned: [Pg.184]    [Pg.541]    [Pg.501]    [Pg.53]    [Pg.49]    [Pg.588]    [Pg.300]    [Pg.190]    [Pg.184]    [Pg.541]    [Pg.501]    [Pg.53]    [Pg.49]    [Pg.588]    [Pg.300]    [Pg.190]    [Pg.178]    [Pg.357]    [Pg.359]    [Pg.354]    [Pg.70]    [Pg.150]    [Pg.196]    [Pg.99]    [Pg.277]    [Pg.739]    [Pg.185]    [Pg.169]    [Pg.136]    [Pg.203]    [Pg.386]    [Pg.1614]    [Pg.492]    [Pg.494]    [Pg.495]    [Pg.154]    [Pg.123]    [Pg.603]    [Pg.196]    [Pg.141]    [Pg.563]   
See also in sourсe #XX -- [ Pg.209 , Pg.501 , Pg.503 ]



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