Architecture evaluation

System qualities that do not correspond to runtime behaviors—modifiability, portability, buildability, and testability—must also be captured as part of requirements-gathering activities, although evaluating them can be more difficult (see Section 12.3, Architecture Evaluation with Scenarios). 

Importantly for direct dynamics calculations, analytic gradients for MCSCF methods [124-126] are available in many standard quantum chemistiy packages. This is a big advantage as numerical gradients require many evaluations of the wave function. The evaluation of the non-Hellmann-Feynman forces is the major effort, and requires the solution of what are termed the coupled-perturbed MCSCF (CP-MCSCF) equations. The large memory requirements of these equations can be bypassed if a direct method is used [233]. Modem computer architectures and codes then make the evaluation of first and second derivatives relatively straightforward in this theoretical framework. 

Buildings—architectural and structural, excludes building servicesf Building evaluation when most process units are located inside buildings ... 

We have developed an approach termed ARBITER (Architecture for Reliable Business Improvement and Technology Evaluation in Research) [25], with associated simulation and visualization capability, that combines... 

Research users need full access to the functional elements of the spectrometer system and require the most efficient and flexible tools for MR sequence and application development. If the measurement methods delivered with the software do not adequately address the specific investigational requirements of a research team, modem NMR software is an open architecture for implementing new and more sophisticated functionality, with full direct access to all hardware controlling parameters. After evaluation, the new functionality can be developed with the help of toolbox functions that allow rapid prototyping and final builds, to enable the new sequence to be executed by non-experienced personnel and then used in routine applications. These toolboxes provide application oriented definitions and connect to standard mechanisms and routine interfaces, such as the geometry editor, configuration parameters or spectrometer adjustments. 

A method of aspirating cells from the tumor via insertion of a small-bore needle into the lesion and aspirating. Commonly used to evaluate lymph nodes or other poorly accessible sites, it has the advantage of being faster and less invasive than other biopsy methods however, it does not preserve the architecture of the tumor and may return cells that are undergoing cell death, which negates histologic analysis. 

A method of obtaining tissue and preserving the tumor architecture. A large-bore needle is inserted into a lesion, where it cuts a core of tissue out that then can be evaluated... 

The essential distinction between the approaches used to formulate and evaluate proteins, compared with conventional low molecular weight drugs, lies in the need to maintain several levels of protein structure and the unique chemical and physical properties that these higher-order structures convey. Proteins are condensation polymers of amino acids, joined by peptide bonds. The levels of protein architecture are typically described in terms of the four orders of structure [23,24] depicted in Fig. 2. The primary structure refers to the sequence of amino acids and the location of any disulfide bonds. Secondary structure is derived from the steric relations of amino acid residues that are close to one another. The alpha-helix and beta-pleated sheet are examples of periodic secondary structure. Tertiary... 

The N-linked pentasaccharide core Man3(GlcNAc)2 glycopeptide bearing the extracellular MMP inducer sequence 517 (emmprin 34—58) has been successfully linked to G(l) PAMAM aminodendrimer by thioester activation (Fig. 63). The resulting octameric 30 kDa construct was obtained in low yield, but was purified by preparative electrophoresis and fully characterized by MALDI-TOF mass spectrometry. The multivalent architecture was built to evaluate the requirement of emmprin multimerization for inducing MMP expression.384... 

In Chapter 5, Spector, Selinger, and Schnur describe such supramolecular architectures, which are formed in water from compounds derived from natural materials that have been altered in their ability to pack. Chirality plays an essential role in this area. However, there are the questions as to why these supramolecular structures are formed, the answers to which can improve approaches to control their architectures and dimensions. These authors evaluate several theories proposed to answer these fundamental questions. 

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