Applications Animal Models

Wexler MR, Halon DA, Teitelbaum A, et al (1984) The prevention of cardiac arrhythmias produced in an animal model by topical application of a phenol preparation in common use for face peeling. Plast Recontsr Surg 73 595-598... 

Restenosis after angioplasty is a situation where these therapies may find an early application. The current animal models evaluate the formation of atherosclerosis or a neointima in the same accelerated and artificially induced... 

In ocular applications, Raman spectroscopy can quickly and objectively assess composite lutein and zeaxanthin concentrations of macular pigment using spatially averaged, integral measurements or images that quantify and map the complete MP distribution with high spatial resolution. Importantly, both variants can be validated with HPLC methods in excised human eyecups and in animal models. 

Stauber J, Lemaire R, Franck J, et al. MALDI imaging of formalin-fixed paraffin-embedded tissues application to model animals of Parkinson disease for biomarker hunting. J. Proteome Res. 2008 7 969-978. 

The establishment of appropriate animal models for biomedical application is essential if new techniques and procedures are to be applied to human conditions. Briefly, the syndrome of plant-induced cleft palate and contracture skeletal malformations in livestock ( crooked calf syndrome ), as described above, is the same whether it is induced by Lupinus, Conium or Nicotiana spp. Likewise, the malformations are described as the same in cattle, sheep, goats, and pigs. While the development of a small ruminant model (goat) was primarily to study the mechanism of action of crooked calf syndrome in cattle, interest in the induced congenital cleft palate and the goat model led to biomedical applications (Panter et al., 2000a). 

The primary clinical application of the antiproliferative effects of the bisindole alkaloids has been in the treatment of human neoplasms. A variety of experimental antitumor systems have been used to study the antitumor properties of these alkaloids in animal models, and much of the information presented for specific compounds in this chapter highlights these effects. Early studies employed syngeneic mice bearing hematopoietic... 

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