Restenosis after angioplasty

Restenosis after angioplasty is a situation where these therapies may find an early application. The current animal models evaluate the formation of atherosclerosis or a neointima in the same accelerated and artificially induced... 

Grigg LE, Kay TW, Valentine PA, et al. Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of coronary artery restenosis after angioplasty, J Am Coll Cardiol 1989 ... 

Steg GR Tahlil O. Aubailly N, et al. Reduction of restenosis after angioplasty in an atheromatous rabbit model by suicide gene therapy, Circulation 1997 96 408-41 I. 

De ite differmces in their mechanisms of action and in vitro activities, pentasaccharide, DX-9065a and TAP have been shown to be effective antithrombotic agents in experimental models of venous thrombosis, coronary artery occlusion, arterial thrombolysis and acute reocclusion, restenosis after angioplasty, dialysis, and DIG. Pentasaccharide has also demonstrated measurable antithrombotic effects in human trials. Both TAP and DX-9065a produce measurable in vitro anticoagulant effects. In contrast, pentasaccharide does not produce an anticoagulant effect by the typical clot based assays. Thus, with fector Xa inhibitors there is not necessarily a correlation between current lab assays and antithrombotic efficacy as there is with heparin. 

In addition to its use as an effective antineoplastic agent, several studies have demonstrated that Taxol is highly effective in preventing restenosis after angioplasty or vascular injury. . The encapsulation of Taxol in polylactic acid microspheres within heparin-chitosan spheres has been shown to provide controlled release of Taxol and... 

Gershony, G., Furman, M., Davis, E., Weintraub, W. and King, S. (1986). Predictors of restenosis after angioplasty in chronic total coronary occlusion. Circulation, 74 (Suppl II), 11-282... 

Low serum HDL-C predisposes patients to the development of MI (90), sudden deathfiOJ), stroke f704,705), carotid artery disease (106), restenosis after angioplasty (107), multivessel disease, and atheromatous plaque formation in the proximial left main coroanry artery (108), and disability and loss of ability to execute activities of daily living in the elderly (109). Low levels of HDL are highly prevalent and occur in approximately 35% of men and 15% of women (24). 

R. Zargham, Preventing restenosis after angioplasty a multistage approach. Clin. ScL (Lond), 2008,114, 257-64. 

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