Coronary circulation

Coronary circulation, 6 (1969) 11 Corticotropin releasing factor receptor antagonists, 41 (2003) 195 Coumarins, metabolism and biological actions, 10 (1974) 85 Cyclic AMP, 12 (1975) 293 Cyclooxygenase-2 (COX-2) inhibitors, 36 (1999) 201... 

The action of nitrates appears to be mediated indirectly through reduction of MVo2 secondary to venodilation and arterial-arteriolar dilation, leading to a reduction in wall stress from reduced ventricular volume and pressure. Direct actions on the coronary circulation include dilation of large and small intramural coronary arteries, collateral dilation, coronary artery stenosis dilation, abolition of normal tone in narrowed vessels, and relief of spasm. 

Coronary circulation, 6 (1969) 11 Coumarins, metabolism and biological actions, 10 (1975) 85... 

C. Ersahin, W. H. Simmons, Inhibition of Both Aminopeptidase P and Angiotensin-Converting Enzyme Prevents Bradykinin Degradation in the Rat Coronary Circulation , J. Cardiovasc. Pharmacol. 1997, 30, 96-101. 

Drug therapy of acute coronary syndromes including unstable angina and non-Q-wave myocardial infarction includes use of aspirin, heparin and anti-ischaemic drugs and is similar in older patients to other age groups. Activation of platelet thromboxane production in the coronary circulation has been demonstrated in unstable angina. The risk of myocardial infarction or death is reduced by approximately 50% by early aspirin therapy in recommended doses of 160-325 mg per day and continued... 

There are various contra-indications for the clinical use of catecholamines. Hyperthyroidism goes together with an abnormal increase of sensitivity of the heart towards the sympathetic transmitters. An atherosclerotic compromised coronary circulation might not be able to sufficiently supply blood... 

Amiodarone relaxes vascular smooth muscle one of its most prominent effects is on the coronary circulation, reducing coronary vascular resistance and improving regional myocardial blood flow. In addition, its effects on the peripheral vascular bed lead to a decrease in left ventricular stroke work and myocardial oxygen consumption. Therefore, amiodarone improves the relationship between myocardial oxygen demand and oxygen supply. IV administration may be associated with profound hypotension requiring volume expansion therapy. 

Major actions of the calcium antagonists on the ischemic heart and coronary circulation, -i, decrease t, increase unchanged t-l, variable effect. 

Digitalis has mild vasoconstrictor action increasing the peripheral resistance. But in CHF patients peripheral resistance decreases due to withdrawal of reflex sympathetic overactivity. Venous tone improves in normal as well as CHF patients. It has no significant effect on coronary circulation. 

Lamping KG et al Muscarinic (M) receptors in coronary circulation. Arterioscler Thromb Vase Biol 2004 24 1253. [PMID 15130910]... 

When CGRP is injected into the central nervous system, it produces a variety of effects, including hypertension and suppression of feeding. When injected into the systemic circulation, the peptide causes hypotension and tachycardia. The hypotensive action of CGRP results from the potent vasodilator action of the peptide indeed, CGRP is the most potent vasodilator yet discovered. It dilates multiple vascular beds, but the coronary circulation is particularly sensitive. 

The effect of papaverine and of other substances on coronary circulation in insufficiency of the myocardium resulting from ligature of coronary vessels was studied by Markova (162) on cats and McEachem et al. (163) on dogs. Intravenous injection of papaverine decreased the mortality from 75 to 50%. Papaverine also partially regenerated the loss of sodium and potassium ions (164). In experimentally induced myocardial infarction in cats (caused by ligature of coronary arteries)... 

B22. Buffon, A., Santini, S. A., Ramazzotti, V., Rigattieri, S., Liuzzo, G., Biasucci, L. M., Crea, F., Giardina, B., and Maseri, A., Large, sustained cardiac lipid peroxidation and reduced antioxidant capacity in die coronary circulation after brief episodes of myocardial ischemia. J. Am. Coll. Cardiol 35, 633-639 (2000). 

Kedev S, Guagliumi G, Valsechi O, Tespili M. Heparin-coated versus uncoated Palmaz-Schatz stent in native coronary circulation. A randomized study with blind angioscopic assessment. Int J Artif Organs 2002 25(5) 461 -469. 

Hojo T Ikeda U, Katsuki T et al. Interleukin 6 expression in coronary circulation after coronary angioplasty as a risk factor for restenosis. Heart 2000 84 83-87. 

Estradiol may improve vascular healing, reduce SMC migration and proliferation, and promote local angiogenesis. Indeed, several animal and human studies have demonstrated the protective effect of estrogen on coronary circulation (30-32). Estrogen not only appears to have a beneficial effect on lipids, but also stimulates NO production by ECs, as well as inhibits expression of the proto-oncogene, c-myc, the activity of which is implicated in the development of intimal hyperplasia (3 1,32). 

The use of GPIIb/llla inhibitors has been extensively studied in numerous large randomized controlled trials involving percutaneous coronary intervention (PCI), The advantages of their use in the coronary circulation that can theoretically... 

Work at the level of the whole ventricle is progressing rapidly as the necessary computing power becomes available (Fig. 9.7). This includes reconstructing some of the arrhythmic processes occurring during ischemia [40], the mechanisms of breakdown into fibrillation [41], modeling of the coronary circulation [34], and the mechanisms of defibrillation [37]. 

Possess a greater affinity for cardiac beta-1 adrenoceptors than for beta-2 adrenoceptors in the bronchial tree, peripheral vasculature and coronary circulation, or for those involved in sugar metabolism where an additional receptor subclass at the time had not yet been defined [73] ... 

Q9 Fibrinolytic drugs, such as streptokinase, are given intravenously to lyse clots in the pulmonary circulation and coronary circulation. Occasionally, the thrombotic mass must be removed surgically. Streptokinase activates plasminogen to form plasmin, which degrades the fibrin in the thrombus. Heparin may be given intravenously to prevent further coagulation. 

---